Glukocerebrozidaza
Glukocerebrozidaza (EC 3.2.1.45, psihozinska hidrolaza, glukosfingozinska glukozilhidrolaza, GlcCer-beta-glukozidaza, beta-D-glukocerebrozidaza, glukozilcerebrozidaza, beta-glukozilkeramidaza, keramidna glukozidaza, glukozilsfingozin beta-glukozidaza, glukozilsfingozin beta-D-glukozidaza) je enzim sa sistematskim imenom D-glukozil-N-acilsfingozin glukohidrolaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Glukocerebrozidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Glukocerebrozidaza tetramer, Human | |||||||||
| Identifikatori | |||||||||
| EC broj | 3.2.1.45 | ||||||||
| CAS broj | 37228-64-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Ovaj enzim takođe deluje na glukozilsfingozin (cf. EC 3.2.1.62 glikozilkeramidaza).
Reference
uredi- ↑ Brady, R.O., Kanfer, J.N. and Shapiro, D. (1966). „The metabolism of glucocerebrosides. I. Preparation and properties of a glucocerebroside-cleaving enzyme from spleen tissue”. J. Biol. Chem. 240: 39-43. PMID 14253443.
- ↑ Vaccaro, A.M., Muscillo, M. and Suzuki, K. (1985). „Characterization of human glucosylsphingosine glucosyl hydrolase and comparison with glucosylceramidase”. Eur. J. Biochem. 146: 315-321. PMID 3967661.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.