Glikoziltransferaza DesVII
Glikoziltransferaza DesVII (EC 2.4.1.277, DesVII) je enzim sa sistematskim imenom dTDP-3-dimetilamino-3,4,6-tridezoksi-alfa-D-glukopiranoza:10-dezoksimetinolid 3-dimetilamino-4,6-didezoksi-alfa-D-glukoziltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Glikoziltransferaza DesVII | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.277 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- dTDP-3-dimetilamino-3,4,6-tridezoksi-alfa-D-glukopiranoza + 10-dezoksimetinolid dTDP + 10-dezoksimetimicin
DesVII je glikoziltransferaza odgovorna za dovanje TDP-D-desosamina na makrolaktone varijabilne veličine prstena.
Reference uredi
- ↑ Borisova, S.A. and Liu, H.W. (2010). „Characterization of glycosyltransferase DesVII and its auxiliary partner protein DesVIII in the methymycin/picromycin biosynthetic pathway”. Biochemistry 49: 8071-8084. PMID 20695498.
- ↑ Borisova, S.A., Kim, H.J., Pu, X. and Liu, H.W. (2008). „Glycosylation of acyclic and cyclic aglycone substrates by macrolide glycosyltransferase DesVII/DesVIII: analysis and implications”. Chembiochem. 9: 1554-1558. PMID 18548476.
- ↑ Hong, J.S., Park, S.J., Parajuli, N., Park, S.R., Koh, H.S., Jung, W.S., Choi, C.Y. and Yoon, Y.J. (2007). „Functional analysis of desVIII homologues involved in glycosylation of macrolide antibiotics by interspecies complementation”. Gene 386: 123-130. PMID 17049185.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.