Glicirhizinatna beta-glukuronidaza
Glicirhizinatna beta-glukuronidaza (EC 3.2.1.128, glicirhizinat beta-glukuronidaza, glicirhizin beta-hidrolaza, glicirhizinsko kiselinska hidrolaza) je enzim sa sistematskim imenom glicirhizinat glukuronazilhidrolaza.[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Glicirhizinatna beta-glukuronidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.2.1.128 | ||||||||
| CAS broj | 102484-56-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- glicirhizin + H2O beta-D-glukuronazil-(1->2)-D-glukuronat + glicirhetinat
Enzim iz Aspergillus niger je specifičan za hidrolizu triterpenoidnog glikozida glicirhizina iz korena Glycyrrhiza sp.
Reference uredi
- ↑ Muro, T., Kuramoto, T., Imoto, K. and Okada, S. (1986). „Purification and some properties of glycyrrhizinic acid hydrolase from Aspergillus niger GRM3”. Agric. Biol. Chem. 50: 687-692.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.