Glicerolna dehidrataza
Glicerolna dehidrataza (EC 4.2.1.30, glicerolna dehidraza, glicerolna hidrolijaza) je enzim sa sistematskim imenom glicerol hidrolijaza (formira 3-hidroksipropanal).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Glicerolna dehidrataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.1.30 | ||||||||
| CAS broj | 9077-68-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- glicerol 3-hidroksipropanal + H2O
Za dejstvo ovog enzima je neophodan kobamidni koenzim.
Reference
uredi- ↑ Forage, R.G. and Foster, M.A. (1982). „Glycerol fermentation in Klebsiella pneumoniae: functions of the coenzyme B12-dependent glycerol and diol dehydratases”. J. Bacteriol. 149: 413-419. PMID 7035429.
- ↑ Schneider, Z., Larsen, E.G., Jacobsen, G., Johnson, B.C. and Pawelkiewicz, J. (1970). „Purification and properties of glycerol dehydrase”. J. Biol. Chem. 245: 3388-3396. PMID 4989992.
- ↑ Schneider, Z. and Pawelkiewicz, J. (1966). „The properties of glycerol dehydratase isolated from Aerobacter aerogenes, and the properties of the apoenzyme subunits”. Acta Biochim. Pol. 13: 311-328. PMID 5962440.
- ↑ Smiley, K.L. and Sobolov, M. (1962). „A cobamide-requiring glycerol dehydrase from an acrolein-forming Lactobacillus”. Arch. Biochem. Biophys. 97: 538-543. PMID 14039344.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.