Glicerofosfoinozitolna inozitolfosfodiestaraza
Glicerofosfoinozitolna inozitolfosfodiestaraza (EC 3.1.4.43, 1,2-ciklična-inozitol-fosfatna fosfodiesteraza, D-mio-inozitol 1:2-ciklična fosfat 2-fosfohidrolaza, D-inozitol 1,2-ciklična fosfat 2-fosfohidrolaza, D-mio-inozitol 1,2-ciklična fosfat 2-fosfohidrolaza, 1-D-mio-inozitol-1,2-ciklična-fosfat 2-inozitolfosfohidrolaza, inozitol-1,2-ciklična-fosfat 2-inozitolfosfohidrolaza) je enzim sa sistematskim imenom 1-(sn-glicero-3-fosfo)-1D-mio-inozitol inozitolfosfohidrolaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Glicerofosfoinozitolna inozitolfosfodiestaraza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.4.43 | ||||||||
| CAS broj | 9076-91-9 (from EC 3.1.4.36), 72414-13-2 (not distinguished from EC 3.1.4.44) | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 1-(sn-glicero-3-fosfo)-1D-mio-inozitol + H2O glicerol + 1D-mio-inozitol 1-fosfat
Ovaj enzim takođe hidrolizuje Ins(ciklična1,2)P do Ins-1-P
Reference uredi
- ↑ Dawson, R.M.C. and Hemington, N. (1977). „A phosphodiesterase in rat kidney cortex that hydrolyses glycerylphosphorylinositol”. Biochem. J. 162: 241-245. PMID 192216.
- ↑ Dawson, R.M.C. and Clarke, N.G. (1972). „D-myoInositol 1:2-cyclic phosphate 2-phosphohydrolase”. Biochem. J. 127: 113-118. PMID 4342209.
- ↑ Dawson, R.M.C. and Clarke, N.G. (1973). „A comparison of D-inositol 1:2-cyclic phosphate 2-phosphohydrolase with other phosphodiesterases of kidney”. Biochem. J. 134: 59-67. PMID 4353088.
- ↑ Ross, T.S. and Majerus, P.W. (1991). „Inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase. Substrate specificity and regulation of activity by phospholipids, metal ion chelators, and inositol 2-phosphate”. J. Biol. Chem. 266: 851-856. PMID 1845995.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.