Geraniltranstransferaza
Geraniltranstransferaza (EC 2.5.1.10, farnezil-difosfatna sintaza, geranilna transferaza I, preniltransferaza, farnezil pirofosfatna sintetaza, farnezilpirofosfatna sintetaza) je enzim sa sistematskim imenom geranil-difosfat:izopentenil-difosfat geraniltranstransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Geraniltranstransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.5.1.10 | ||||||||
| CAS broj | 37277-79-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- geranil difosfat + izopentenil difosfat difosfat + (2E,6E)-farnezil difosfat
Neke forme ovog enzima takođe koriste dimetilalil difosfat kao supstrat.
Reference uredi
- ↑ Lynen, F., Agranoff, B.W., Eggerer, H., Henning, V. and Möslein, E.M. (1959). „Zur Biosynthese der Terpene. VI. γ,γ-Dimethyl-allyl-pyrophosphat und Geranyl-pyrophosphat, biologische Vorstufen des Squalens”. Angew. Chem. 71: 657-663.
- ↑ Ogura, K., Nishino, T. and Seto, S. (1968). „The purification of prenyltransferase and isopentenyl pyrophosphate isomerase of pumpkin fruit and their some properties”. J. Biochem. (Tokyo) 64: 197-203. PMID 4303505.
- ↑ Reed, B.C. and Rilling, H. (1975). „Crystallization and partial characterization of prenyltransferase from avian liver”. Biochemistry 14: 50-54. PMID 1109590.
- ↑ Takahashi, I. and Ogura, K. (1981). „Farnesyl pyrophosphate synthetase from Bacillus subtilis”. J. Biochem. (Tokyo) 89: 1581-1587. PMID 6792191.
- ↑ Takahashi, I. and Ogura, K. (1982). „Prenyltransferases of Bacillus subtilis: undecaprenyl pyrophosphate synthetase and geranylgeranyl pyrophosphate synthetase”. J. Biochem. (Tokyo) 92: 1527-1537. PMID 6818223.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.