Geranilgeranil difosfat reduktaza
Geranilgeranil difosfat reduktaza (EC 1.3.1.83, geranilgeranilna reduktaza, CHL P) je enzim sa sistematskim imenom geranilgeranil-difosfat:NADP+ oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Geranilgeranil difosfat reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.3.1.83 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- fitil difosfat + 3 NADP+ geranilgeranil difosfat + 3 NADPH + 3 H+
Ovaj enzim takođe deluje na geranilgeranil-hlorofil a. Reakcija se odvija u tri koraka.
Reference uredi
- ↑ Soll, J., Schultz, G., Rudiger, W. and Benz, J. (1983). „Hydrogenation of geranylgeraniol : two pathways exist in spinach chloroplasts”. Plant Physiol. 71: 849-854. PMID 16662918.
- ↑ Tanaka, R., Oster, U., Kruse, E., Rudiger, W. and Grimm, B. (1999). „Reduced activity of geranylgeranyl reductase leads to loss of chlorophyll and tocopherol and to partially geranylgeranylated chlorophyll in transgenic tobacco plants expressing antisense RNA for geranylgeranyl reductas”. Plant Physiol. 120: 695-704. PMID 10398704.
- ↑ Keller, Y., Bouvier, F., d'Harlingue, A. and Camara, B. (1998). „Metabolic compartmentation of plastid prenyllipid biosynthesis—evidence for the involvement of a multifunctional geranylgeranyl reductase”. Eur. J. Biochem. 251: 413-417. PMID 9492312.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.