Geranilfarnezil difosfat sintaza
Geranilfarnezil difosfat sintaza (EC 2.5.1.81, FGPP sintaza, (sve-E) geranilfarnezil difosfatna sintaza, GFPS, Fgs) je enzim sa sistematskim imenom geranilgeranil-difosfat:izopentenil-difosfat transtransferaza (dodaje 1 izopentenilnu jedinicu).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Geranilfarnezil difosfat sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.5.1.81 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- geranilgeranil difosfat + izopentenil difosfat (2E,6E,10E,14E)-geranilfarnezil difosfat + difosfat
Enzim iz metanosarcina mazei učestvuje u biosintezi poliprenilnog bočnog lanca metanofenazina.
Reference
uredi- ↑ Ogawa, T., Yoshimura, T. and Hemmi, H. (2010). „Geranylfarnesyl diphosphate synthase from Methanosarcina mazei: Different role, different evolution”. Biochem. Biophys. Res. Commun. 393: 16-20. PMID 20097171.
- ↑ Tachibana, A., Yano, Y., Otani, S., Nomura, N., Sako, Y. and Taniguchi, M. (2000). „Novel prenyltransferase gene encoding farnesylgeranyl diphosphate synthase from a hyperthermophilic archaeon, Aeropyrum pernix. Molecular evolution with alteration in product specificity”. Eur. J. Biochem. 267: 321-328. PMID 10632701.
- ↑ Tachibana, A. (1994). „A novel prenyltransferase, farnesylgeranyl diphosphate synthase, from the haloalkaliphilic archaeon, Natronobacterium pharaonis”. FEBS Lett. 341: 291-294. PMID 8137956.
- ↑ Lee, P.C., Mijts, B.N., Petri, R., Watts, K.T. and Schmidt-Dannert, C. (2004). „Alteration of product specificity of Aeropyrum pernix farnesylgeranyl diphosphate synthase (Fgs) by directed evolution”. Protein Eng. Des. Sel. 17: 771-777. PMID 15548566.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.