Gentisat 1,2-dioksigenaza
Gentisat 1,2-dioksigenaza (EC 1.13.11.4, gentisatna oksigenaza, 2,5-dihidroksibenzoatna dioksigenaza, gentisatna dioksigenaza, oksidaza gentisinske kiseline) je enzim sa sistematskim imenom gentisat:kiseonik 1,2-oksidoreduktaza (deciklizacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju:
| Gentisat 1,2-dioksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.13.11.4 | ||||||||
| CAS broj | 9029-48-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 2,5-dihidroksibenzoat + O2 maleilpiruvat
Za rad ovog enzima neohodan je Fe2+.
Reference uredi
- ↑ Hayaishi, O. (1963). „Direct oxygenation by O2, oxygenases”. u: Boyer, P.D., Lardy, H. and Myrbäck, K.. The Enzymes. 8 (2nd izd.). New York: Academic Press. str. 353-371.
- ↑ Sugiyama, S., Yano, K., Komagata, K. and Arima, K. (1960). „Metabolites of aromatic compounds by microbes. Part VII. Gentisic acid oxidase”. Bull. Agric. Chem. Soc. Jpn 24: 243-248.
- ↑ Sugiyama, S., Yano, K. and Arima, K. (1960). „Metabolites of aromatic compounds by microbes. Part VII. Further studies of gentisic acid oxidase”. Bull. Agric. Chem. Soc. Jpn 24: 249-254.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
- Hayaishi, O. (1963). „Direct oxygenation by O2, oxygenases”. u: Boyer, P.D., Lardy, H. and Myrbäck, K.. The Enzymes. 8 (2nd izd.). New York: Academic Press. str. 353-371.