Galaktozilkeramid sulfotransferaza
Galaktozilkeramid sulfotransferaza (EC 2.8.2.11, GSase, 3'-fosfoadenozin-5'-fosfosulfat-cerebrozid sulfotransferaza, galaktocerebrozidna sulfotransferaza, galaktolipidna sulfotransferaza, glikolipidna sulfotransferaza, glikosfingolipidna sulfotransferaza) je enzim sa sistematskim imenom 3'-fosfoadenilil-sulfat:galaktozilkeramid 3'-sulfotransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Galaktozilkeramid sulfotransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.8.2.11 | ||||||||
| CAS broj | 2622964 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 3'-fosfoadenilil sulfat + galaktozilkeramid adenozin 3',5'-bisfosfat + galaktozilkeramidsulfat
Ovaj enzim takođe deluje na laktozilkeramid.
Reference uredi
- ↑ McKhann, G.M., Levy, R. and Ho, W. (1965). „Metabolism of sulfatides. I. The effect of galactocerebrosides on the synthesis of sulfatides”. Biochem. Biophys. Res. Commun. 20: 109-113. PMID 5850675.
- ↑ Sakakibara, N., Gasa, S., Kamio, K., Makita, A. and Koyanagi, T. (1989). „Association of elevated sulfatides and sulfotransferase activities with human renal cell carcinoma”. Cancer Res. 49: 335-339. PMID 2562926.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.