Galaktozilgalaktozilglukozilkeramidaza
Galaktozilgalaktozilglukozilkeramidaza (EC 3.2.1.47, triheksozil keramid galaktozidaza, keramidna triheksozidaza, keramidtriheksozidna alfa-galaktozidaza, triheksozilkeramidna alfa-galaktozidaza, keramidtriheksozidaza) je enzim sa sistematskim imenom alfa-D-galaktozil-(1->4)-beta-D-galaktozil-(1->4)-beta-D-glukozil-(1<->1)-keramid galaktohidrolaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Galaktozilgalaktozilglukozilkeramidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.2.1.47 | ||||||||
| CAS broj | 2601625 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- alfa-D-galaktozil-(1->4)-beta-D-galaktozil-(1->4)-beta-D-glukozil-(1<->1)-keramid + H2O D-galaktoza + beta-D-galaktozil-(1->4)-beta-D-glukozil-(1<->1)-keramid
Reference uredi
- ↑ Brady, R.O., Gal, A.E., Bradley, R.M. and Matensson, E. (1967). „The metabolism of ceramide trihexosides. I. Purification and properties of an enzyme that cleaves the terminal galactose molecule of galactosylgalactosylglucosylceramide”. J. Biol. Chem. 242: 1021-1026. PMID 6020428.
- ↑ Mapes, C.A. and Sweeley, C.C. (1972). „Substrate specificity of ceramide trihexosidase”. FEBS Lett. 25: 279-281. PMID 11946769.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.