GPR45
(Preusmjereno sa stranice G protein-spregnuti receptor 45)
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GPR45, G protein-spregnuti receptor 45, je protein koji je kod čoveka kodiran GPR45 genom.[1][2]
| G protein-spregnuti receptor 45 | |||||||||||
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| Identifikatori | |||||||||||
| Simboli | GPR45; PSP24; PSP24(ALPHA); PSP24A | ||||||||||
| Vanjski ID | OMIM: 604838 MGI: 2135882 HomoloGene: 5228 IUPHAR: GPR45 GeneCards: GPR45 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 11250 | 93690 | |||||||||
| Ensembl | ENSG00000135973 | ENSMUSG00000041907 | |||||||||
| UniProt | Q9Y5Y3 | Q148B5 | |||||||||
| RefSeq (mRNA) | NM_007227 | NM_053107 | |||||||||
| RefSeq (protein) | NP_009158 | NP_444337 | |||||||||
| Lokacija (UCSC) | Chr 2: 105.22 - 105.23 Mb | Chr 1: 42.9 - 42.98 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Ovaj gen ne sadrži introne. On kodira člana familije G protein-spregnutih receptora. Članovi te proteinske familije sadrže sedam transmembranskih domena i posreduju signalizacione procese u unutrašnjosti ćelije putem aktivacije heterotrimernih G proteina. Smatra se da ovaj protein deluje u centralnom nervnom sistemu.[2]
Literatura uredi
- ↑ Marchese A, Sawzdargo M, Nguyen T, Cheng R, Heng HH, Nowak T, Im DS, Lynch KR, George SR, O'dowd BF (May 1999). „Discovery of three novel orphan G-protein-coupled receptors”. Genomics 56 (1): 12–21. DOI:10.1006/geno.1998.5655. PMID 10036181.
- ↑ 2,0 2,1 „Entrez Gene: GPR45 G protein-coupled receptor 45”.
Dodatna literatura uredi
- Kawasawa Y, Kume K, Nakade S, et al. (2000). „Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45.”. Biochem. Biophys. Res. Commun. 276 (3): 952–6. DOI:10.1006/bbrc.2000.3569. PMID 11027574.
- Kawasawa Y, Kume K, Izumi T, Shimizu T (2000). „Mammalian PSP24s (alpha and beta isoforms) are not responsive to lysophosphatidic acid in mammalian expression systems.”. Biochem. Biophys. Res. Commun. 276 (3): 957–64. DOI:10.1006/bbrc.2000.3570. PMID 11027575.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Hillier LW, Graves TA, Fulton RS, et al. (2005). „Generation and annotation of the DNA sequences of human chromosomes 2 and 4.”. Nature 434 (7034): 724–31. DOI:10.1038/nature03466. PMID 15815621.