Galaktozilgalaktozilglukozilkeramid b-D-acetilgalaktozaminiltransferaza
Galaktozilgalaktozilglukozilkeramid b-D-acetilgalaktozaminiltransferaza (EC 2.4.1.79, uridin difosfoacetilgalaktozamin-galaktozilgalaktozilglukozilkeramid acetilgalaktozaminiltransferaza, globozidna sintetaza, UDP-N-acetilgalaktozamin:globotriaozilkeramid beta-3-N-acetilgalaktozaminiltransferaza, galaktozilgalaktozilglukozilkeramid beta-D-acetilgalaktozaminiltransferaza, UDP-N-acetilgalaktozamin:globotriaozilkeramid beta1,3-N-acetilgalaktozaminiltransferaza, globozidna sintaza, gUDP-N-acetil-D-galaktozamin:D-galaktozil-1,4-D-galaktozil-1,4-D-glukozilkeramid beta-N-acetil-D-galaktozaminiltransferaza, beta3GalNAc-T1, UDP-N-acetil-D-galaktozamin:alfa-D-galaktozil-(1->4)-beta-D-galaktozil-(1->4)-beta-D-glukozilkeramid 3III-beta-N-acetil-D-galaktozaminiltransferaza, UDP-N-acetil-D-galaktozamin:alfa-D-galaktozil-(1->4)-beta-D-galaktozil-(1->4)-beta-D-glukozil-(1<->1)-keramid 3III-beta-N-acetil-D-galaktozaminiltransferaza) je enzim sa sistematskim imenom UDP-N-acetil-D-galaktozamin:alfa-D-galaktozil-(1->4)-beta-D-galaktozil-(1->4)-beta-D-glukozil-(1<->1)-keramid III3-beta-N-acetil-D-galaktozaminiltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Galaktozilgalaktozilglukozilkeramid b-D-acetilgalaktozaminiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.79 | ||||||||
| CAS broj | 62213-46-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- UDP-N-acetil-D-galaktozamin + alfa-D-galaktozil-(1->4)-beta-D-galaktozil-(1->4)-beta-D-glukozil-(1<->1)-keramid UDP + N-acetil-beta-D-galaktozaminil-(1->3)-alfa-D-galaktozil-(1->4)-beta-D-galaktozil-(1->4)-beta-D-glukozil-(1<->1)-keramid
Globozid je neutralni glikosfingolipid u ljudskim eritrocitima i deluje kao krvno-grupni P-antigen.
Reference uredi
- ↑ Chien, J.-L., Williams, T. and Basu, S. (1973). „Biosynthesis of a globoside-type glycosphingolipid by a β-N-acetylgalactosaminyltransferase from embryonic chicken brain”. J. Biol. Chem. 248: 1778-1785. PMID 4632917.
- ↑ Ishibashi, T., Kijimoto, S. and Makita, A. (1974). „Biosynthesis of globoside and Forssman hapten from trihexosylceramide and properties of β-N-acetyl-galactosaminyltransferase of guinea pig kidney”. Biochim. Biophys. Acta 337: 92-106. PMID 4433547.
- ↑ Taniguchi, N. and Makita, A. (1984). „Purification and characterization of UDP-N-acetylgalactosamine: globotriaosylceramide β-3-N-acetylgalactosaminyltransferase, a synthase of human blood group P antigen, from canine spleen”. J. Biol. Chem. 259: 5637-5642. PMID 6425294.
- ↑ Okajima, T., Nakamura, Y., Uchikawa, M., Haslam, D.B., Numata, S.I., Furukawa, K., Urano, T. and Furukawa, K. (2000). „Expression cloning of human globoside synthase cDNAs. Identification of β3Gal-T3 as UDP-N-acetylgalactosamine:globotriaosylceramide β1,3-N-acetylgalactosaminyltransferase”. J. Biol. Chem. 275: 40498-40503. PMID 10993897.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.