GTPaza proteinske sinteze
GTPaza proteinske sinteze (EC 3.6.5.3, elongacioni faktor (EF), inicijacioni faktor (IF), faktor peptidnog oslobađanja ili terminacije) je enzim sa sistematskim imenom GTP fosfohidrolaza (pomoć pri iRNK translaciji).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| GTPaza proteinske sinteze | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.6.5.3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- GTP + H2O GDP + fosfat
Ova grupa enzima pripada familiji proteina koji učestvuju u prokariotskoj, kao i u eukariotskoj, proteinskoj sintezi.
Reference
uredi- ↑ Kurzchalia, T.V., Bommer, U.A., Babkina, G.T. and Karpova, G.G. (1984). „GTP interacts with the γ-subunit of eukaryotic initiation factor EIF-2”. FEBS Lett. 175: 313-316. PMID 6566615.
- ↑ Kisselev, L.L. and Frolova, L.Yu. (1995). „Termination of translation in eukaryotes”. Biochem. Cell Biol. 73: 1079-1086. PMID 8722024.
- ↑ Rodnina, M.V., Savelsberg, A., Katunin, V.I. and Wintermeyer, W. (1997). „Hydrolysis of GTP by elongation factor G drives tRNA movement on the ribosome”. Nature 385: 37-41. PMID 8985244.
- ↑ Freistroffer, D.V., Pavlov, M.Y., MacDougall, J., Buckingham, R.H. and Ehrenberg, M. (1997). „Release factor RF3 in E. coli accelerates the dissociation of release factors RF1 and RF2 from the ribosome in a GTP-dependent manner”. EMBO J. 16: 4126-4133. PMID 9233821.
- ↑ Krab, I.M. and Parmeggiani, A. (1998). „EF-Tu, a GTPase odyssey”. Biochim. Biophys. Acta 1443: 1-22. PMID 9838020.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.