Četica prepoznavanja signala
(Preusmjereno sa stranice GTP fosfohidrolaza (pomoć pri proteinskoj sintezi))
Četica prepoznavanja signala (EC 3.6.5.4) je enzim sa sistematskim imenom GTP fosfohidrolaza (pomoć pri proteinskoj sintezi).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Četica prepoznavanja signala | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.6.5.4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- GTP + H2O GDP + fosfat
Dejstvo ovih enzima je vezano za prepoznavanje signalnih čestica.
Reference uredi
- ↑ Connolly, T. and Gilmore, R. (1989). „The signal recognition particle receptor mediates the GTP-dependent displacement of SRP from the signal sequence of the nascent polypeptide”. Cell 57: 599-610. PMID 2541918.
- ↑ Connolly, T., Rapiejko, P.J. and Gilmore, R. (1991). „Requirement of GTP hydrolysis for dissociation of the signal recognition particle from its receptor”. Science 252: 1171-1173. PMID 1851576.
- ↑ Miller, J.D., Wilhelm, H., Gierasch, L., Gilmore, R. and Walter, P. (1993). „GTP binding and hydrolysis by the signal recognition particle during initiation of protein translocation”. Nature 366: 351-354. PMID 8247130.
- ↑ Freymann, D.M., Keenan, R.J., Stroud, R.M. and Walter, P. (1997). „Structure of the conserved GTPase domain of the signal recognition particle”. Nature 385: 361-364. PMID 9002524.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.