Glukozil-3-fosfoglicerat sintaza
(Preusmjereno sa stranice GPG synthase)
Glukozil-3-fosfoglicerat sintaza (EC 2.4.1.266, GpgS protein, GPG sintaza, glukozilfosfoglicerat sintaza) je enzim sa sistematskim imenom NDP-glukoza:3-fosfo-D-glicerat 2-alfa-D-glukoziltransferaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Glukozil-3-fosfoglicerat sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.266 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- NDP-glukoza + 3-fosfo-D-glicerat NDP + 2-O-(alfa-D-glukopiranozil)-3-fosfo-D-glicerat
Ovaj enzim učestvuje u biosintezi 2-O-(alfa-D-glukopiranozil)-D-glicerata.
Reference uredi
- ↑ Costa, J., Empadinhas, N. and da Costa, M.S. (2007). „Glucosylglycerate biosynthesis in the deepest lineage of the bacteria: characterization of the thermophilic proteins GpgS and GpgP from Persephonella marina”. J. Bacteriol. 189: 1648-1654. PMID 17189358.
- ↑ Costa, J., Empadinhas, N., Goncalves, L., Lamosa, P., Santos, H. and da Costa, M.S. (2006). „Characterization of the biosynthetic pathway of glucosylglycerate in the archaeon Methanococcoides burtonii”. J. Bacteriol. 188: 1022-1030. PMID 16428406.
- ↑ Empadinhas, N., Albuquerque, L., Mendes, V., Macedo-Ribeiro, S. and da Costa, M.S. (2008). „Identification of the mycobacterial glucosyl-3-phosphoglycerate synthase”. FEMS Microbiol. Lett. 280: 195-202. PMID 18221489.
- ↑ Pereira, P.J., Empadinhas, N., Albuquerque, L., Sa-Moura, B., da Costa, M.S. and Macedo-Ribeiro, S. (2008). „Mycobacterium tuberculosis glucosyl-3-phosphoglycerate synthase: structure of a key enzyme in methylglucose lipopolysaccharide biosynthesis”. PLoS One 3: #e3748-e3748. PMID 19015727.
- ↑ Gest, P., Kaur, D., Pham, H.T., van der Woerd, M., Hansen, E., Brennan, P.J., Jackson, M. and Guerin, M.E. (2008). „Preliminary crystallographic analysis of GpgS, a key glucosyltransferase involved in methylglucose lipopolysaccharide biosynthesis in Mycobacterium tuberculosis”. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 64: 1121-1124. PMID 19052364.
- ↑ Kaur, D., Pham, H., Larrouy-Maumus, G., Riviere, M., Vissa, V., Guerin, M.E., Puzo, G., Brennan, P.J. and Jackson, M. (2009). „Initiation of methylglucose lipopolysaccharide biosynthesis in mycobacteria”. PLoS One 4: #e544-e5447. PMID 19421329.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.