GNAT3

Vezujući protein guaninskog nukleotida, alfa jedinica 3
Identifikatori
Simboli	GNAT3; GDCA
Vanjski ID	OMIM: 139395 MGI: 3588268 HomoloGene: 24284 GeneCards: GNAT3 Gene
Ontologija gena
Molekularna funkcija	• vezivanje G-protein spregnutog receptora; • aktivnost GTPaza; • aktivnost prenosa signala; • GTP vezivanje;
Celularna komponenta	• fotoreceptorski spoljašnje segment; • fotoreceptorski unutrašnji segment; • citoplazma; • heterotrimerni G proteinski kompleks;
Biološki proces	• detekcija hemijskog stimulusa koji učestvuje u senzornoj percepciji gorkog ukusa; • GTP katabolički proces; • signalni put adenilat ciklazom modulisanog G protein spregnutog receptora;
Ortolozi

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Vezujući protein guaninskog nukleotida G(t), alfa jedinica 3 (gustducin alfa-3 lanac) je protein koji je kod ljudi kodiran GNAT3 genom.^[1]

Gustducin alfa-3 lanac je podjedinica heterotrimerinog proteina gustducina koji je odgovoran za osnovne ukuse.

Reference

↑ „Entrez Gene: guanine nucleotide binding protein”.

Literatura

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Scherer SW, Cheung J, MacDonald JR, et al. (2003). „Human chromosome 7: DNA sequence and biology.”. Science 300 (5620): 767–72. DOI:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Rozengurt N, Wu SV, Chen MC, et al. (2006). „Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon.”. Am. J. Physiol. Gastrointest. Liver Physiol. 291 (5): G792-802. DOI:10.1152/ajpgi.00074.2006. PMID 16728727.
Huang L, Shanker YG, Dubauskaite J, et al. (1999). „Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium.”. Nat. Neurosci. 2 (12): 1055–62. DOI:10.1038/15981. PMID 10570481.
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Strausberg RL, Feingold EA, Grouse LH, et al. (2002). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Luttrell LM (2008). „Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.”. Mol. Biotechnol. 39 (3): 239–64. DOI:10.1007/s12033-008-9031-1. PMID 18240029.
Margolskee RF, Dyer J, Kokrashvili Z, et al. (2007). „T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1.”. Proc. Natl. Acad. Sci. U.S.A. 104 (38): 15075–80. DOI:10.1073/pnas.0706678104. PMID 17724332.
Takami S, Getchell TV, McLaughlin SK, et al. (1994). „Human taste cells express the G protein alpha-gustducin and neuron-specific enolase.”. Brain Res. Mol. Brain Res. 22 (1-4): 193–203. DOI:10.1016/0169-328X(94)90047-7. PMID 8015379.
Jang HJ, Kokrashvili Z, Theodorakis MJ, et al. (2007). „Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1.”. Proc. Natl. Acad. Sci. U.S.A. 104 (38): 15069–74. Bibcode 2007PNAS..10415069J. DOI:10.1073/pnas.0706890104. PMID 17724330.
Li X, Staszewski L, Xu H, et al. (2002). „Human receptors for sweet and umami taste.”. Proc. Natl. Acad. Sci. U.S.A. 99 (7): 4692–6. DOI:10.1073/pnas.072090199. PMC 123709. PMID 11917125.
Fehr J, Meyer D, Widmayer P, et al. (2007). „Expression of the G-protein alpha-subunit gustducin in mammalian spermatozoa.”. J. Comp. Physiol. A Neuroethol. Sens. Neural. Behav. Physiol. 193 (1): 21–34. DOI:10.1007/s00359-006-0168-8. PMID 17021831.
Lambright DG, Noel JP, Hamm HE, Sigler PB (1994). „Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein.”. Nature 369 (6482): 621–8. DOI:10.1038/369621a0. PMID 8208289.

[entrez-1] „Entrez Gene: guanine nucleotide binding protein”.

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