GMP sintaza (hidrolizacija glutamina)
GMP sintaza (hidrolizacija glutamina) (EC 6.3.5.2, GMP sintetaza (glutaminska hidroliza), guanilatna sintetaza (glutaminska hidroliza), guanozin monofosfatna sintetaza (glutaminska hidroliza), ksantozin 5'-fosfatna amidotransferaza, guanozin 5'-monofosfatna sintetaza) je enzim sa sistematskim imenom ksantozin-5'-fosfat:L-glutamin amido-ligaza (formira AMP).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| GMP sintaza (hidrolizacija glutamina) | |||||||||
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| Identifikatori | |||||||||
| EC broj | 6.3.5.2 | ||||||||
| CAS broj | 37318-71-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Reference
uredi- ↑ Abrams, R. and Bentley, M. (1959). „Biosynthesis of nucleic acid purines. III. Guanosine 5′-phosphate formation from xanthosine 5′-phosphate and L-glutamine”. Arch. Biochem. Biophys. 79: 91-110.
- ↑ Lagerkvist, U. (1958). „Biosynthesis of guanosine 5′-phosphate. II. Amination of xanthosine 5′-phosphate by purified enzyme from pigeon liver”. J. Biol. Chem. 233: 143-149. PMID 13563458.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.