Hipoksantin fosforiboziltransferaza
Hipoksantin fosforiboziltransferaza (EC 2.4.2.8, IMP pirofosforilaza, transfosforibozidaza, hipoksantin---guanin fosforiboziltransferaza, guaninska fosforiboziltransferaza, GPRT, HPRT, guanozin 5'-fosfat pirofosforilaza, IMP-GMP pirofosforilaza, HGPRTase, 6-hidroksipurin fosforiboziltransferaza, 6-merkaptopurin fosforiboziltransferaza, GMP pirofosforilaza, guanin-hipoksantin fosforiboziltransferaza, guanozin fosforiboziltransferaza, guanilat pirofosforilaza, guanilinska pirofosforilaza, inozinatna pirofosforilaza, inozin 5'-fosfatna pirofosforilaza, inozinsko kiselinska pirofosforilaza, inozinska pirofosforilaza, 6-merkaptopurinska fosforiboziltransferaza, purin-6-tiolna fosforiboziltransferaza) je enzim sa sistematskim imenom IMP:difosfat fosfo-D-riboziltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Hipoksantin fosforiboziltransferaza | |||||||||
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| Identifikatori | |||||||||
| EC broj | 2.4.2.8 | ||||||||
| CAS broj | 9016-12-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- IMP + difosfat hipoksantin + 5-fosfo-alfa-D-riboza 1-difosfat
Guanin i 6-merkaptopurin mogu da zamene hipoksantin.
Reference
uredi- ↑ Flaks, J.G. (1963). „Nucleotide synthesis from 5-phosphoribosylpyrophosphate”. Methods Enzymol. 6: 136-158.
- ↑ Kornberg, A., Lieberman, I. and Simms, E.S. (1955). „Enzymatic synthesis of purine nucleotides”. J. Biol. Chem. 215: 417-427. PMID 14392175.
- ↑ Lukens, L.N. and Herrington, K.A. (1957). „Enzymic formation of 6-mercaptopurine ribotide”. Biochim. Biophys. Acta 24: 432-433. PMID 13436452.
- ↑ Remy, C.N., Remy, W.T. and Buchanan, J.M. (1955). „Biosynthesis of the purines. VIII. Enzymatic synthesis and utilization of α-5-phosphoribosylpyrophosphate”. J. Biol. Chem. 217: 885-895. PMID 13271449.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.