Ekso-(1-4)-α-D-glukanska lijaza
(Preusmjereno sa stranice GLase)
Ekso-(1-4)-α-D-glukanska lijaza (EC 4.2.2.13, alfa-(1->4)-glukan 1,5-anhidro-D-fruktozna eliminaza, alfa-1,4-glukan ekso-lijaza, alfa-1,4-glukan lijaza, Glaza) je enzim sa sistematskim imenom (1->4)-alfa-D-glukan ekso-4-lijaza (formira 1,5-anhidro-D-fruktoza).[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Ekso-(1-4)-α-D-glukanska lijaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.2.13 | ||||||||
| CAS broj | 148710-18-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- linearni alfa-glukan (N-1) 1,5-anhidro-D-fruktoza + D-glukoza
Ovaj enzim katalizuje sekvencinu degradaciju (1->4)-alfa-D-glukana sa neredukujućeg kraja.
Reference uredi
- ↑ Yu, S., Kenne, L., Pedersén, M. (1993). „α-1,4-Glucan lyase, a new class of starch/glycogen degrading enzyme. I. Efficient purification and characterization from red seaweeds”. Biochim. Biophys. Acta 1156: 313-320. PMID 8461323.
- ↑ Yu, S., Pedersén, M. (1993). „α-1,4-Glucan lyase, a new class of starch/glycogen degrading enzyme. II. Subcellular localization and partial amino-acid sequence”. Planta 191: 137-142. PMID 7763826.
- ↑ Yu, S., Ahmad, T., Kenne, L. and Pedersén, M. (1995). „α-1,4-Glucan lyase, a new class of starch/glycogen degrading enzyme. III. Substrate specificity, mode of action, and cleavage mechanism”. Biochim. Biophys. Acta 1244: 1-9. PMID 7766642.
- ↑ Yu, S., Christensen, T.M., Kragh, K.M., Bojsen, K. and Marcussen, J. (1997). „Efficient purification, characterization and partial amino acid sequencing of two α-1,4-glucan lyases from fungi”. Biochim. Biophys. Acta 1339: 311-320. PMID 9187252.
- ↑ Yu, S., Bojsen, K., Svensson, B. and Marcussen, J. (1999). „α-1,4-glucan lyases producing 1,5-anhydro-D-fructose from starch and glycogen have sequence similarity to α-glucosidases”. Biochim. Biophys. Acta 1433: 1-15. PMID 10446355.
- ↑ Lee, S.S., Yu, S. and Withers, S.G. (2002). „α-1,4-Glucan lyase performs a trans-elimination via a nucleophilic displacement followed by a syn-elimination”. J. Am. Chem. Soc. 124: 4948-4949. PMID 11982345.
- ↑ Lee, S.S., Yu, S. and Withers, S.G. (2003). „Detailed dissection of a new mechanism for glycoside cleavage: α-1,4-glucan lyase”. Biochemistry 42: 13081-13090. PMID 14596624.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.