GABA transporter tip 1

(Preusmjereno sa stranice GABA transporter 1)
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GABA transporter 1 (GAT-1, natrijum- i hlorid-zavisni GABA transporter 1) je protein koji je kod ljudi kodiran SLC6A1 genom.[1][2]

Familija trasportera rastvorka‎ 6 (neurotransmiterni transporter, GABA), član 1
Identifikatori
SimboliSLC6A1; GABATHG; GABATR; GAT1
Vanjski IDOMIM137165 MGI95627 HomoloGene2290 GeneCards: SLC6A1 Gene
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez6529232333
EnsemblENSG00000157103ENSMUSG00000030310
UniProtP30531P31648
RefSeq (mRNA)NM_003042.3NM_178703.4
RefSeq (protein)NP_003033.3NP_848818.1
Lokacija (UCSC)Chr 3:
11.03 - 11.08 Mb
Chr 6:
114.28 - 114.32 Mb
PubMed pretraga[1][2]

Funkcija

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GAT-1 je transporter gama-aminobuterne kiseline (GABA), koji uklanja GABA iz sinaptičkog rascepat.[3]

Interakcije

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SLC6A1 formira interakcije sa STX1A.[4][5][6]

Reference

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  1. Huang F, Shi LJ, Heng HH, Fei J, Guo LH (February 1996). „Assignment of the human GABA transporter gene (GABATHG) locus to chromosome 3p24-p25”. Genomics 29 (1): 302–4. DOI:10.1006/geno.1995.1253. PMID 8530094. 
  2. „Entrez Gene: SLC6A1 solute carrier family 6 (neurotransmitter transporter, GABA), member 1”. 
  3. Hirunsatit R, George ED, Lipska BK, Elwafi HM, Sander L, Yrigollen CM, Gelernter J, Grigorenko EL, Lappalainen J, Mane S, Nairn AC, Kleinman JE, Simen AA (January 2009). „Twenty-one-base-pair insertion polymorphism creates an enhancer element and potentiates SLC6A1 GABA transporter promoter activity”. Pharmacogenet. Genomics 19 (1): 53–65. DOI:10.1097/FPC.0b013e328318b21a. PMID 19077666. 
  4. Beckman, M L; Bernstein E M, Quick M W (August 1998). „Protein kinase C regulates the interaction between a GABA transporter and syntaxin 1A”. J. Neurosci. (UNITED STATES) 18 (16): 6103–12. ISSN 0270-6474. PMID 9698305. 
  5. Quick, Michael W (April 2002). „Substrates regulate gamma-aminobutyric acid transporters in a syntaxin 1A-dependent manner”. Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (8): 5686–91. DOI:10.1073/pnas.082712899. ISSN 0027-8424. PMC 122832. PMID 11960023. 
  6. Deken, S L; Beckman M L, Boos L, Quick M W (October 2000). „Transport rates of GABA transporters: regulation by the N-terminal domain and syntaxin 1A”. Nat. Neurosci. (UNITED STATES) 3 (10): 998–1003. DOI:10.1038/79939. ISSN 1097-6256. PMID 11017172. 

Literatura

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Vidi još

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