G-butirobetain dioksigenaza
G-butirobetain dioksigenaza (EC 1.14.11.1, alfa-butirobetainska hidroksilaza, gama-butirobetainska hidroksilaza, butirobetainska hidroksilaza) je enzim sa sistematskim imenom 4-trimetilamoniobutanoat,2-oksoglutarat:kiseonik oksidoreduktaza (3-hidroksilacija).[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
| G-butirobetain dioksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 1.14.11.1 | ||||||||
| CAS broj | 9045-31-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- 4-trimetilamoniobutanoat + 2-oksoglutarat + O2 3-hidroksi-4-trimetilamoniobutanoat + sukcinat + CO2
Za rad ovog enzima se neophodni Fe2+ i askorbat.[2]
Reference
uredi- ↑ Lindstedt, G. and Lindstedt, S. (1970). „Cofactor requirements of γ-butyrobetaine hydroxylase from rat liver”. J. Biol. Chem. 245: 4178-4186. PMID 4396068.
- ↑ Leung IKH, Krojer TJ, Kochan GT, Henry L, von Delft F, Claridge TDW, Oppermann U, McDonough MA, Schofield CJ (December 2010). „Structural and mechanistic studies on γ-butyrobetaine hydroxylase”. Chem. Biol. 17 (12): 1316–24. DOI:10.1016/j.chembiol.2010.09.016. PMID 21168767.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.