Ftalilna amidaza
Ftalilna amidaza (EC 3.5.1.79) je enzim sa sistematskim imenom ftalil-amid amidohidrolaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Ftalilna amidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.5.1.79 | ||||||||
| CAS broj | 169150-79-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- ftalilamid + H2O ftalna kiselina + supstituisani amin
Enzim iz Xanthobacter agilis hidrolizuje ftalizovane aminokiseline, peptide, beta-laktame, aromatične i alifatične amine.
Reference uredi
- ↑ Briggs, B.S., Kreuzman, A.J., Whitesitt, C., Yeh, W.K., Zmijewski, M. (1996). „Discovery, purification, and properties of o-phthalyl amidase from Xanthobacter agilis”. J. Mol. Catal., B Enzym. 2: 53-69.
- ↑ Black, T.D., Briggs, B.S., Evans, R., Muth, W.L., Vangala, S., Zmijewski, M.J. (1996). „o-Phthalyl amidase in the synthesis of Loracarbef: process development using this novel biocatalyst”. Biotechnol. Lett. 18: 875-880.
- ↑ Costello, C., Kreuzman, A., Zmijewski, M. (1996). „Selective deprotection of phthalyl protected proteins”. Tetrahedron Lett. 37: 7469-7472.
- ↑ us 5445959, Šablon:Cite patent/authors, "Enzyme from microbial source: phthalyl amidase", published 1995, assigned to .
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.