Fragilizin
Fragilizin (EC 3.4.24.74, Bacteroides fragilis (entero)toksin) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Fragilizin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.74 | ||||||||
| CAS broj | 188596-63-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Širokoa proteolitička specifičnost, između ostalog dolazi do hidrolize veza -Gly-Leu-, -Met-Leu-, -Phe-Leu-, -Cys-Leu-, Leu-Gly
Smatra se da je ovaj enzim uzročnik dijareje kod životinja i ljudi.
Reference
uredi- ↑ Moncrief, J.S., Obiso, R., Jr., Barroso, L.A., Kling, J.J., Wright, R.L., Van Tassell, R.L., Lyerly, D.M. and Wilkins, T.D. (1995). „The enterotoxin of Bacteroides fragilis is a metalloprotease”. Infect. Immun. 63: 175-181. PMID 7806355.
- ↑ Obiso, R.J., Jr., Lyerly, D.M., Van Tassell, R.L. and Wilkins, T.D. (1995). „Proteolytic activity of the Bacteroides fragilis enterotoxin causes fluid secretion and intestinal damage in vivo”. Infect. Immun. 63: 3820-3826. PMID 7558286.
- ↑ Donelli, G., Fabbri, A. and Fiorentini, C. (1996). „Bacteroides fragilis enterotoxin induces cytoskeletal changes and surface blebbing in HT-29 cells”. Infect. Immun. 64: 113-119. PMID 8557328.
- ↑ Koshy, S.S., Montrose, M.H. and Sears, C.L. (1996). „Human intestinal epithelial cells swell and demonstrate actin rearrangement in response to the metalloprotease toxin of Bacteroides fragilis”. Infect. Immun. 64: 5022-5028. PMID 8945541.
- ↑ Kling, J.J., Wright, R.L., Moncrief, J.S. and Wilkins, T.D. (1997). „Cloning and characterization of the gene for the metalloprotease enterotoxin of Bacteroides fragilis”. FEMS Microbiol. Lett. 146: 279-284. PMID 9011050.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.