Fosfoglukonat dehidrogenaza (dekarboksilacija)
Fosfoglukonat dehidrogenaza (dekarboksilacija) (EC 1.1.1.44, fosfoglukonska kiselina dehidrogenaza, 6-fosfoglukonska dehidrogenaza, 6-fosfoglukonska karboksilaza, 6-fosfoglukonatna dehidrogenaza (dekarboksilacija), 6-fosfo-D-glukonatna dehidrogenaza) je enzim sa sistematskim imenom 6-fosfo-D-glukonat:NADP+ 2-oksidoreduktaza (dekarboksilacija).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Fosfoglukonat dehidrogenaza (dekarboksilacija) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Dimer fosfoglukonat dehidrogenaze (ovca) | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.1.1.44 | ||||||||
| CAS broj | 9073-95-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- 6-fosfo-D-glukonat + NADP+ D-ribuloza 5-fosfat + CO2 + NADPH
Pojedini preparati redukuju NAD+, kao i NADP+.
Reference uredi
- ↑ Dickens, F. and Glock, G.E. (1951). „Direct oxidation of glucose-6-phosphate, 6-phosphogluconate and pentose-5-phosphate by enzymes of animal origin”. Biochem. J. 50: 81-95. PMID 14904376.
- ↑ Pontremoli, S., de Flora, A., Grazi, E., Mangiarotti, G., Bonsignore, A. and Horecker, B.L. (1961). „Purification and properties of β-L-hydroxy acid dehydrogenase. II. Isolation of β-keto-L-gluconic acid, an intermediate in L-xylulose biosynthesis”. J. Biol. Chem. 236: 2975-2980. PMID 14487824.
- ↑ Scott, D.B.M. and Cohen, S.S. (1953). „The oxidative pathway of carbohydrate metabolism in Escherichia coli. 1. The isolation and properties of glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase”. Biochem. J. 55: 23-33. PMID 13093611.
- ↑ Scott, D.B.M. and Cohen, S.S. (1957). „The oxidative pathway of carbohydrate metabolism in Escherichia coli. 5. Isolation and identification of ribulose phosphate produced from 6-phosphogluconate by the dehydrogenase of E. coli”. Biochem. J. 65: 686-689. PMID 13426085.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.