Fosfatidilinozitol N-acetilglukozaminiltransferaza
Fosfatidilinozitol N-acetilglukozaminiltransferaza (EC 2.4.1.198, UDP-N-acetil-D-glukozamin:fosfatidilinozitol N-acetil-D-glukozaminiltransferaza, uridin difosfoacetilglukozamin alfa1,6-acetil-D-glukozaminiltransferaza) je enzim sa sistematskim imenom UDP-N-acetil-D-glukozamin:1-fosfatidil-1D-mio-inozitol 6-(N-acetil-alfa-D-glukozaminil)transferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Fosfatidilinozitol N-acetilglukozaminiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.198 | ||||||||
| CAS broj | 144388-35-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- UDP-N-acetil-D-glukozamin + 1-fosfatidil-1D-mio-inozitol UDP + 6-(N-acetil-alfa-D-glukozaminil)-1-fosfatidil-1D-mio-inozitol
Ovaj enzim učestvuje u prvom koraku formiranja glikozilfosfatidilinozitolnog (GPI) akera kod eukariota.
Reference uredi
- ↑ Doering, T.L., Masteron, W.J., Englund, P.T. and Hart, G.W. (1989). „Biosynthesis of the glycosyl phosphatidylinositol membrane anchor of the trypanosome variant surface glycoprotein. Origin of the non-acetylated glucosamine”. J. Biol. Chem. 264: 11168-11173. PMID 2525555.
- ↑ Watanabe, R., Inoue, N., Westfall, B., Taron, C.H., Orlean, P., Takeda, J. and Kinoshita, T. The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H (1998). „, PIG-C and GPI1”. EMBO J. 17: 877-885. PMID 9463366.
- ↑ Watanabe, R., Murakami, Y., Marmor, M.D., Inoue, N., Maeda, Y., Hino, J., Kangawa, K., Julius, M. and Kinoshita, T. (2000). „Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2”. EMBO J. 19: 4402-4411. PMID 10944123.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.