Fosfatidilholin desaturaza
Fosfatidilholin desaturaza (EC 1.3.1.35, oleatna desaturaza, linoleatna sintaza, oleoil-KoA desaturaza, oleoilfosfatidilholinska desaturaza) je enzim sa sistematskim imenom 1-acil-2-oleoil-sn-glicero-3-fosfoholin:NAD+ Delta12-oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Fosfatidilholin desaturaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.3.1.35 | ||||||||
| CAS broj | 72536-70-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 1-acil-2-oleoil-sn-glicero-3-fosfoholin + NAD+ 1-acil-2-linoleoil-sn-glicero-3-fosfoholin + NADH + H+
Ovaj enzim takođe desaturiše fosfatidilholin koji sadrži oleoil grupu na O-2 glicerolnog ostatka.
Reference uredi
- ↑ Pugh, E.L. and Kates, M. (1975). „Characterization of a membrane-bound phospholipid desaturase system of Candida lipolytica”. Biochim. Biophys. Acta 380: 442-453. PMID 166662.
- ↑ Slack, C.R., Roughan, P.G. and Browse, J. (1979). „Evidence for an oleoyl phosphatidylcholine desaturase in microsomal preparations from cotyledons of safflower (Carthamus tinctorius) seed”. Biochem. J. 179: 649-656. PMID 475773.
- ↑ Stymne, S. and Åppelqvist, L.-A. (1978). „The biosynthesis of linoleate from oleoyl-CoA via oleoyl-phosphatidylcholine in microsomes of developing safflower seeds”. Eur. J. Biochem. 90: 223-229. PMID 710426.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.