Format-tetrahidrofolatna ligaza
Format-tetrahidrofolatna ligaza (EC 6.3.4.3, formiltetrahidrofolatna sintetaza, 10-formiltetrahidrofolatna sintetaza, tetrahidrofolna formilaza, tetrahidrofolatna formilaza) je enzim sa sistematskim imenom format:tetrahidrofolat ligaza (formira ADP).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Format-tetrahidrofolatna ligaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Identifikatori | |||||||||
| EC broj | 6.3.4.3 | ||||||||
| CAS broj | 9023-66-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- ATP + format + tetrahidrofolat ADP + fosfat + 10-formiltetrahidrofolat
Kod eukariota se javlja trifunkcionalni enzim.
Reference
uredi- ↑ Jaenicke, L. and Brode, E. (1961). „Untersuchungen über Einkohlenstoffkörper. I. Die Tetrahydrofolatformylase aus Taubenleber. Rinigung und Mechanismus”. Biochem. Z. 334: 108-132. PMID 13789141.
- ↑ Long, C.W., Levitzki, A., Houston, L.L and Koshland, D.E., Jr. (1969). „Subunit structures and interactions of CTP synthetase”. Fed. Proc. 28: 342-342.
- ↑ Rabinowitz, J.C. and Pricer, W.E. (1962). „Formyltetrahydrofolate synthetase. I. Isolation and crystallization of the enzyme”. J. Biol. Chem. 237: 2898-2902. PMID 14489619.
- ↑ Whiteley, H.R., Osborn, M.J. and Huennekens, F.M. (1959). „Purification and properties of the formate-activating enzyme from Micrococcus aerogenes”. J. Biol. Chem. 234: 1538-1543. PMID 13654413.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.