Fluoroacetil-KoA tioesteraza
Fluoroacetil-KoA tioesteraza (EC 3.1.2.29) je enzim sa sistematskim imenom fluoroacetil-KoA hidrolaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Fluoroacetil-KoA tioesteraza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.2.29 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- fluoroacetil-KoA + H2O fluoroacetat + KoA
Fluoroacetat je ekstremno toksičan.
Reference uredi
- ↑ Meyer, J.J.M., Grobbelaar, N., Vleggaar, R. and Louw, A.I. (1992). „Fluoroacetyl-coenzyme-A hydrolase-like activity in Dichapetalum cymosum”. J. Plant Physiol. 139: 369-372.
- ↑ Huang, F., Haydock, S.F., Spiteller, D., Mironenko, T., Li, T.L., O'Hagan, D., Leadlay, P.F. and Spencer, J.B. (2006). „The gene cluster for fluorometabolite biosynthesis in Streptomyces cattleya: a thioesterase confers resistance to fluoroacetyl-coenzyme A”. Chem. Biol. 13: 475-484. PMID 16720268.
- ↑ Dias, M.V., Huang, F., Chirgadze, D.Y., Tosin, M., Spiteller, D., Dry, E.F., Leadlay, P.F., Spencer, J.B. and Blundell, T.L. (2010). „Structural basis for the activity and substrate specificity of fluoroacetyl-CoA thioesterase FlK”. J. Biol. Chem. 285: 22495-22504. PMID 20430898.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.