Fizarolisin
Fizarolisin (EC 3.4.21.103, Dictyostelium discoideum aspartička proteinaza, Dictyostelium discoideum aspartička proteinaza E, Physarum flavicomum aspartička proteinaza, Physarum policephalum kiselinska proteinaza, Physarum aspartička proteinaza, fizaropepsin) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Fizarolisin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.21.103 | ||||||||
| CAS broj | 94949-28-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- Zgrušavanje mleka. Preferentno razlaganje Gly8-Ser u B lancu insulina je najbrže, tome sledi Leu11-Val, Cys(SO3H)19-Gly i Phe24-Phe.
Ovaj enzim priapada peptidaznoj familiji S53.
Reference
uredi- ↑ Henney, H.R. and Tavana, G. (1982). „Purification and some properties of an intracellular acid (carboxyl) proteinase from differentiating haploid cells of Physarum flavicomum”. Exp. Mycol. 6: 161-170.
- ↑ Murakami-Murofushi, K., Hiratsuka, A. and Ohta, J. (1984). „A novel acid protease from haploid amoebae of Physarum polycephalum, and its changes during mating and subsequent differentiation into diploid plasmodia”. Cell Struct. Funct. 9: 311-315.
- ↑ North, M.J. and Whyte, A. (1984). „Purification and characterization of two acid proteinases from Dictyostelium discoideum”. J. Gen. Microbiol. 130: 123-134.
- ↑ Wlodawer, A., Li, M., Gustchina, A., Oyama, H., Dunn, B.M. and Oda, K. (2003). „Structural and enzymatic properties of the sedolisin family of serine-carboxyl peptidases”. Acta Biochim. Pol. 50: 81-102. PMID 12673349.
- ↑ Nishii, W., Ueki, T., Miyashita, R., Kojima, M., Kim, Y.T., Sasaki, N., Murakami-Murofushi, K. and Takahashi, K. (2003). „Structural and enzymatic characterization of physarolisin (formerly physaropepsin) proves that it is a unique serine-carboxyl proteinase”. Biochem. Biophys. Res. Commun. 301: 1023-1029. PMID 12589815.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.