Feri-helat reduktaza (NADPH)
(Preusmjereno sa stranice Fe(II):NADP+ oxidoreductase)
Feri-helat reduktaza (NADPH) (EC 1.16.1.9, feri helatna reduktaza, gvožđe helatna reduktaza, NADPH:Fe3+-EDTA reduktaza, NADPH-zavisna feri reduktaza, ZQJH (gen)) je enzim sa sistematskim imenom Fe(II):NADP+ oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Feri-helat reduktaza (NADPH) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.16.1.9 | ||||||||
| CAS broj | 120720-17-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 2 Fe(II) + 2 apo-siderofor + NADP+ + H+ 2 Fe(III)-siderofor + NADPH
Ovaj enzim sadrži FAD. Readkcija je katalizovana u reverznom smeru.
Reference uredi
- ↑ Bamford, V.A., Armour, M., Mitchell, S.A., Cartron, M., Andrews, S.C. and Watson, K.A. (2008). „Preliminary X-ray diffraction analysis of YqjH from Escherichia coli: a putative cytoplasmic ferri-siderophore reductase”. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 64: 792-796. PMID 18765906.
- ↑ Wang, S., Wu, Y. and Outten, F.W. (2011). „Fur and the novel regulator YqjI control transcription of the ferric reductase gene yqjH in Escherichia coli”. J. Bacteriol. 193: 563-574. PMID 21097627.
- ↑ Miethke, M., Hou, J. and Marahiel, M.A. (2011). „The Siderophore-Interacting Protein YqjH Acts as a Ferric Reductase in Different Iron Assimilation Pathways of Escherichia coli”. Biochemistry: -. PMID 22098718.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.