Eksodezoksiribonukleaza (lambda-indukovana)
Eksodezoksiribonukleaza (lambda-indukovana) (EC 3.1.11.3, lambda eksonukleaza, fagom lambda indukovana eksonukleaza, Escherichia coli eksonukleaza IV, E. coli eksonukleaza IV, eksodezoksiribonukleaza IV, eksonukleaza IV) je enzim sa sistematskim imenom '.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Eksodezoksiribonukleaza (lambda-indukovana) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.11.3 | ||||||||
| CAS broj | 37367-70-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- Eksonukleolitičko razlaganje u 5'- ka 3'- smeru čime se formiraju nukleozid 5'-fosfati
Ova enzim preferentno deluje na dvolačanu DNK.
Reference
uredi- ↑ Lindahl, T., Gally, J.A. and Edelman, G.M. (1969). „Deoxyribonuclease IV: a new exonuclease from mammalian tissues”. Proc. Natl. Acad. Sci. USA 62: 597-603. PMID 5256235.
- ↑ Little, J.W. (1967). „An exonuclease induced by bacteriophage lambda. II. Nature of the enzymatic reaction”. J. Biol. Chem. 242: 679-686. PMID 6017737.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.