EPHB3
(Preusmjereno sa stranice ETK2)
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Receptor 3 efrinskog tipa B je protein koji je kod ljudi kodiran EPHB3 genom.[1][2]
| EPH receptor B3 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Dostupne strukture | |||||||||||
| 3P1I, 3ZFY | |||||||||||
| Identifikatori | |||||||||||
| Simboli | EPHB3; ETK2; HEK2; TYRO6 | ||||||||||
| Vanjski ID | OMIM: 601839 MGI: 104770 HomoloGene: 20938 GeneCards: EPHB3 Gene | ||||||||||
| EC broj | 2.7.10.1 | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 2049 | 13845 | |||||||||
| Ensembl | ENSG00000182580 | ENSMUSG00000005958 | |||||||||
| UniProt | P54753 | P54754 | |||||||||
| Ref. Sekv. (iRNK) | NM_004443 | NM_010143 | |||||||||
| Ref. Sekv. (protein) | NP_004434 | NP_034273 | |||||||||
| Lokacija (UCSC) | Chr 3: 184.28 - 184.3 Mb | Chr 16: 21.2 - 21.22 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Efrinski receptori i njihovi ligandi, efrini, posreduju brojne procese razvića, posebno u nervnom sistemu. Na bazi njihovih struktura i sekvenci, efrini se dele u efrinsku klasu A (EFNA), koja se fiksira na membrani putem glikozilfosfatidilinozitolne veze, i efrinsku klasu B (EFNB), koji su transmembranski proteini. Eph familija receptora se deli u dve groupe na osnovu sličnosti njihovih sekvenci ekstracelularnog domena i njihovog afiniteta vezivanja liganda efrina A i efrina B. Efrinski receptori su najveća podgrupa receptora tirozinske kinazne (RTK) familije. Protein kodiran ovim genom je receptor za efrinske-B članove familije.[2]
Interakcije uredi
EPHB3 formira interakcije sa MLLT4[3] i RAS p21 proteinskim aktivatorom 1.[4]
Reference uredi
- ↑ Bohme B, Holtrich U, Wolf G, Luzius H, Grzeschik KH, Strebhardt K, Rubsamen-Waigmann H (Oct 1993). „PCR mediated detection of a new human receptor-tyrosine-kinase, HEK 2”. Oncogene 8 (10): 2857–62. PMID 8397371.
- ↑ 2,0 2,1 „Entrez Gene: EPHB3 EPH receptor B3”.
- ↑ Hock, B; Böhme B; Karn T; Yamamoto T; Kaibuchi K; Holtrich U; Holland S; Pawson T i dr.. (Aug 1998). „PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor”. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 95 (17): 9779–84. DOI:10.1073/pnas.95.17.9779. ISSN 0027-8424. PMC 21413. PMID 9707552.
- ↑ Hock, B; Böhme B; Karn T; Feller S; Rübsamen-Waigmann H; Strebhardt K (Jul 1998). „Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions”. Oncogene (ENGLAND) 17 (2): 255–60. DOI:10.1038/sj.onc.1201907. ISSN 0950-9232. PMID 9674711.
Literatura uredi
- Flanagan JG, Vanderhaeghen P (1998). „The ephrins and Eph receptors in neural development.”. Annu. Rev. Neurosci. 21: 309–45. DOI:10.1146/annurev.neuro.21.1.309. PMID 9530499.
- Zhou R (1998). „The Eph family receptors and ligands.”. Pharmacol. Ther. 77 (3): 151–81. DOI:10.1016/S0163-7258(97)00112-5. PMID 9576626.
- Holder N, Klein R (1999). „Eph receptors and ephrins: effectors of morphogenesis.”. Development 126 (10): 2033–44. PMID 10207129.
- Wilkinson DG (2000). „Eph receptors and ephrins: regulators of guidance and assembly.”. Int. Rev. Cytol. 196: 177–244. DOI:10.1016/S0074-7696(00)96005-4. PMID 10730216.
- Xu Q, Mellitzer G, Wilkinson DG (2001). „Roles of Eph receptors and ephrins in segmental patterning.”. Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993–1002. DOI:10.1098/rstb.2000.0635. PMC 1692797. PMID 11128993.
- Wilkinson DG (2001). „Multiple roles of EPH receptors and ephrins in neural development.”. Nat. Rev. Neurosci. 2 (3): 155–64. DOI:10.1038/35058515. PMID 11256076.
- Böhme B, VandenBos T, Cerretti DP, et al. (1996). „Cell-cell adhesion mediated by binding of membrane-anchored ligand LERK-2 to the EPH-related receptor human embryonal kinase 2 promotes tyrosine kinase activity.”. J. Biol. Chem. 271 (40): 24747–52. DOI:10.1074/jbc.271.40.24747. PMID 8798744.
- Ephnomenclaturecommittee, (1997). „Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee.”. Cell 90 (3): 403–4. DOI:10.1016/S0092-8674(00)80500-0. PMID 9267020.
- Bergemann AD, Zhang L, Chiang MK, et al. (1998). „Ephrin-B3, a ligand for the receptor EphB3, expressed at the midline of the developing neural tube.”. Oncogene 16 (4): 471–80. DOI:10.1038/sj.onc.1201557. PMID 9484836.
- Hock B, Böhme B, Karn T, et al. (1998). „Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions.”. Oncogene 17 (2): 255–60. DOI:10.1038/sj.onc.1201907. PMID 9674711.
- Hock B, Böhme B, Karn T, et al. (1998). „PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor.”. Proc. Natl. Acad. Sci. U.S.A. 95 (17): 9779–84. DOI:10.1073/pnas.95.17.9779. PMC 21413. PMID 9707552.
- Ciossek T, Monschau B, Kremoser C, et al. (1998). „Eph receptor-ligand interactions are necessary for guidance of retinal ganglion cell axons in vitro.”. Eur. J. Neurosci. 10 (5): 1574–80. DOI:10.1046/j.1460-9568.1998.00180.x. PMID 9751130.
- Adams RH, Wilkinson GA, Weiss C, et al. (1999). „Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis.”. Genes Dev. 13 (3): 295–306. DOI:10.1101/gad.13.3.295. PMC 316426. PMID 9990854.