EPH receptor A2
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EPH receptor A2 (efrinski receptor 2 tipa A) protein je koji je kod ljudi kodiran EPHA2 genom.[1][2]
| EPH receptor A2 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
 PDB prikaz baziran na 1mqb. | |||||||||||
| Dostupne strukture | |||||||||||
| 1MQB, 2E8N, 2K9Y, 2KSO, 2X10, 2X11, 3C8X, 3CZU, 3FL7, 3HEI, 3HPN, 3KKA, 3MBW, 3MX0, 3SKJ, 4P2K, 4P2W, 4PDO | |||||||||||
| Identifikatori | |||||||||||
| Simboli | EPHA2; ARCC2; CTPA; CTPP1; CTRCT6; ECK | ||||||||||
| Vanjski ID | OMIM: 176946 MGI: 95278 HomoloGene: 20929 GeneCards: EPHA2 Gene | ||||||||||
| EC broj | 2.7.10.1 | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 1969 | 13836 | |||||||||
| Ensembl | ENSG00000142627 | ENSMUSG00000006445 | |||||||||
| UniProt | P29317 | Q03145 | |||||||||
| Ref. Sekv. (iRNK) | NM_004431 | NM_010139 | |||||||||
| Ref. Sekv. (protein) | NP_004422 | NP_034269 | |||||||||
| Lokacija (UCSC) | Chr 1: 16.45 - 16.48 Mb | Chr 4: 141.3 - 141.33 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Ovaj gen je pripadnik grupe efrinskih receptora iz familije proteinskih turozinskih kinaza. EPH i EPH-srodni receptori uzimaju učešća u posredovanju događaja razvića, posebno u nervnom sistemu. Receptori EPH podfamilije tipično imaju jedan kinazni domen, ekstracelularni region koji sadrži domen bogat cisteinom i dva ponavljanja fibronektinskog tipa III. Efrinski receptori se dele u dve grupe na bazi sličnosti sekvenci njihovih ekstracelularnih domena i njihovih afiniteta vezivanja liganda efrina A i efrina B.[2]
Interakcije uredi
EPH receptor A2 formira interakcije sa PIK3R1,[3] Grb2,[4] ACP1[5] i SHC1.[4]
Reference uredi
- ↑ Sulman EP, Tang XX, Allen C, Biegel JA, Pleasure DE, Brodeur GM, Ikegaki N (April 1997). „ECK, a human EPH-related gene, maps to 1p36.1, a common region of alteration in human cancers”. Genomics 40 (2): 371–4. DOI:10.1006/geno.1996.4569. PMID 9119409.
- ↑ 2,0 2,1 „Entrez Gene: EPHA2 EPH receptor A2”.
- ↑ Pandey, A; Lazar D F; Saltiel A R; Dixit V M (December 1994). „Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity”. J. Biol. Chem. (UNITED STATES) 269 (48): 30154–7. ISSN 0021-9258. PMID 7982920.
- ↑ 4,0 4,1 Pratt, Rebecca L; Kinch Michael S (October 2002). „Activation of the EphA2 tyrosine kinase stimulates the MAP/ERK kinase signaling cascade”. Oncogene (England) 21 (50): 7690–9. DOI:10.1038/sj.onc.1205758. ISSN 0950-9232. PMID 12400011.
- ↑ Kikawa, Keith D; Vidale Derika R; Van Etten Robert L; Kinch Michael S (October 2002). „Regulation of the EphA2 kinase by the low molecular weight tyrosine phosphatase induces transformation”. J. Biol. Chem. (United States) 277 (42): 39274–9. DOI:10.1074/jbc.M207127200. ISSN 0021-9258. PMID 12167657.
Literatura uredi
- Flanagan JG, Vanderhaeghen P (1998). „The ephrins and Eph receptors in neural development.”. Annu. Rev. Neurosci. 21: 309–45. DOI:10.1146/annurev.neuro.21.1.309. PMID 9530499.
- Zhou R (1998). „The Eph family receptors and ligands.”. Pharmacol. Ther. 77 (3): 151–81. DOI:10.1016/S0163-7258(97)00112-5. PMID 9576626.
- Holder N, Klein R (1999). „Eph receptors and ephrins: effectors of morphogenesis.”. Development 126 (10): 2033–44. PMID 10207129.
- Wilkinson DG (2000). „Eph receptors and ephrins: regulators of guidance and assembly.”. Int. Rev. Cytol. 196: 177–244. DOI:10.1016/S0074-7696(00)96005-4. PMID 10730216.
- Xu Q, Mellitzer G, Wilkinson DG (2001). „Roles of Eph receptors and ephrins in segmental patterning.”. Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993–1002. DOI:10.1098/rstb.2000.0635. PMC 1692797. PMID 11128993.
- Wilkinson DG (2001). „Multiple roles of EPH receptors and ephrins in neural development.”. Nat. Rev. Neurosci. 2 (3): 155–64. DOI:10.1038/35058515. PMID 11256076.
- Kinch MS, Carles-Kinch K (2003). „Overexpression and functional alterations of the EphA2 tyrosine kinase in cancer.”. Clin. Exp. Metastasis 20 (1): 59–68. DOI:10.1023/A:1022546620495. PMID 12650608.
- Walker-Daniels J, Hess AR, Hendrix MJ, Kinch MS (2003). „Differential regulation of EphA2 in normal and malignant cells.”. Am. J. Pathol. 162 (4): 1037–42. DOI:10.1016/S0002-9440(10)63899-0. PMC 1851246. PMID 12651595.
- Lindberg RA, Hunter T (1991). „cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases”. Mol. Cell. Biol. 10 (12): 6316–24. PMC 362907. PMID 2174105.
- Pandey A, Shao H, Marks RM, et al. (1995). „Role of B61, the ligand for the Eck receptor tyrosine kinase, in TNF-alpha-induced angiogenesis”. Science 268 (5210): 567–9. DOI:10.1126/science.7536959. PMID 7536959.
- Pandey A, Duan H, Dixit VM (1995). „Characterization of a novel Src-like adapter protein that associates with the Eck receptor tyrosine kinase”. J. Biol. Chem. 270 (33): 19201–4. DOI:10.1074/jbc.270.33.19201. PMID 7543898.
- Ruiz JC, Robertson EJ (1994). „The expression of the receptor-protein tyrosine kinase gene, eck, is highly restricted during early mouse development”. Mech. Dev. 46 (2): 87–100. DOI:10.1016/0925-4773(94)90078-7. PMID 7918100.
- Davis S, Gale NW, Aldrich TH, et al. (1994). „Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity”. Science 266 (5186): 816–9. DOI:10.1126/science.7973638. PMID 7973638.
- Pandey A, Lazar DF, Saltiel AR, Dixit VM (1994). „Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity”. J. Biol. Chem. 269 (48): 30154–7. PMID 7982920.
- Ganju P, Shigemoto K, Brennan J, et al. (1994). „The Eck receptor tyrosine kinase is implicated in pattern formation during gastrulation, hindbrain segmentation and limb development”. Oncogene 9 (6): 1613–24. PMID 8183555.
- Gale NW, Holland SJ, Valenzuela DM, et al. (1996). „Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis”. Neuron 17 (1): 9–19. DOI:10.1016/S0896-6273(00)80276-7. PMID 8755474.
- Kozlosky CJ, VandenBos T, Park L, et al. (1997). „LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain”. Cytokine 9 (8): 540–9. DOI:10.1006/cyto.1997.0199. PMID 9245480.
- Ephnomenclaturecommittee, (1997). „Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee”. Cell 90 (3): 403–4. DOI:10.1016/S0092-8674(00)80500-0. PMID 9267020.