EPH receptor B1
(Preusmjereno sa stranice EPHB1)
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Receptor 1 efrinskog tipa B je protein koji je kod ljudi kodiran EPHB1 genom.[1][2]
| EPH receptor B1 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
 PDB prikaz baziran na 2djs. | |||||||||||
| Dostupne strukture | |||||||||||
| 2DJS, 2EAO, 3ZFX | |||||||||||
| Identifikatori | |||||||||||
| Simboli | EPHB1; ELK; EPHT2; Hek6; NET | ||||||||||
| Vanjski ID | OMIM: 600600 MGI: 1096337 HomoloGene: 20936 GeneCards: EPHB1 Gene | ||||||||||
| EC broj | 2.7.10.1 | ||||||||||
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| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 2047 | 270190 | |||||||||
| Ensembl | ENSG00000154928 | ENSMUSG00000032537 | |||||||||
| UniProt | P54762 | Q8CBF3 | |||||||||
| Ref. Sekv. (iRNK) | NM_004441 | NM_001168296 | |||||||||
| Ref. Sekv. (protein) | NP_004432 | NP_001161768 | |||||||||
| Lokacija (UCSC) | Chr 3: 134.32 - 134.98 Mb | Chr 9: 101.92 - 102.35 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Funkcija uredi
Ephrinski receptori i njihovi ligandi, efrini, posreduju brojne procese razvića, posebno u nervnom sistemu. Na bazi njihovih struktura i sekvenci, efrini se dele u efrinsku klasu A (EFNA), koja se fiksira na membrani putem glikozilfosfatidilinozitolne veze, i efrinsku klasu B (EFNB), koji su transmembranski proteini. Eph familija receptora se deli u dve groupe na osnovu sličnosti njihovih sekvenci ekstracelularnog domena i njihovog afiniteta vezivanja liganda efrina A i efrina B. Efrinski receptori su najveća podgrupa receptora tirozinske kinazne (RTK) familije. Protein kodiran ovim genom je receptor za efrinske-B članove familije.[3][2]
Interakcije uredi
EPH receptor B1 formira interakcije sa GRB7,[4] ACP1[5] i NCK1.[6]
Reference uredi
- ↑ Tang XX, Biegel JA, Nycum LM, Yoshioka A, Brodeur GM, Pleasure DE, Ikegaki N (Aug 1996). „cDNA cloning, molecular characterization, and chromosomal localization of NET(EPHT2), a human EPH-related receptor protein-tyrosine kinase gene preferentially expressed in brain”. Genomics 29 (2): 426–37. DOI:10.1006/geno.1995.9985. PMID 8666391.
- ↑ 2,0 2,1 „Entrez Gene: EPHB1 EPH receptor B1”.
- ↑ „Entrez Gene: EPHB2 EPH receptor B2”.
- ↑ Han, Dong Cho; Shen Tang-Long; Miao Hui; Wang Bingcheng; Guan Jun-Lin (Nov 2002). „EphB1 associates with Grb7 and regulates cell migration”. J. Biol. Chem. (United States) 277 (47): 45655–61. DOI:10.1074/jbc.M203165200. ISSN 0021-9258. PMID 12223469.
- ↑ Stein, E; Lane A A; Cerretti D P; Schoecklmann H O; Schroff A D; Van Etten R L; Daniel T O (Mar 1998). „Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses”. Genes Dev. (UNITED STATES) 12 (5): 667–78. DOI:10.1101/gad.12.5.667. ISSN 0890-9369. PMC 316584. PMID 9499402.
- ↑ Stein, E; Huynh-Do U; Lane A A; Cerretti D P; Daniel T O (Jan 1998). „Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase”. J. Biol. Chem. (UNITED STATES) 273 (3): 1303–8. DOI:10.1074/jbc.273.3.1303. ISSN 0021-9258. PMID 9430661.
Literatura uredi
- Flanagan JG, Vanderhaeghen P (1998). „The ephrins and Eph receptors in neural development.”. Annu. Rev. Neurosci. 21: 309–45. DOI:10.1146/annurev.neuro.21.1.309. PMID 9530499.
- Zhou R (1998). „The Eph family receptors and ligands.”. Pharmacol. Ther. 77 (3): 151–81. DOI:10.1016/S0163-7258(97)00112-5. PMID 9576626.
- Abrahamson DR, Robert B, Hyink DP, et al. (1998). „Origins and formation of microvasculature in the developing kidney.”. Kidney Int. Suppl. 67: S7–11. DOI:10.1046/j.1523-1755.1998.06702.x. PMID 9736245.
- Holder N, Klein R (1999). „Eph receptors and ephrins: effectors of morphogenesis.”. Development 126 (10): 2033–44. PMID 10207129.
- Wilkinson DG (2000). „Eph receptors and ephrins: regulators of guidance and assembly.”. Int. Rev. Cytol. 196: 177–244. DOI:10.1016/S0074-7696(00)96005-4. PMID 10730216.
- Xu Q, Mellitzer G, Wilkinson DG (2001). „Roles of Eph receptors and ephrins in segmental patterning.”. Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993–1002. DOI:10.1098/rstb.2000.0635. PMC 1692797. PMID 11128993.
- Wilkinson DG (2001). „Multiple roles of EPH receptors and ephrins in neural development.”. Nat. Rev. Neurosci. 2 (3): 155–64. DOI:10.1038/35058515. PMID 11256076.
- Larose L, Gish G, Shoelson S, Pawson T (1993). „Identification of residues in the beta platelet-derived growth factor receptor that confer specificity for binding to phospholipase C-gamma 1.”. Oncogene 8 (9): 2493–9. PMID 7689724.
- Davis S, Gale NW, Aldrich TH, et al. (1994). „Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity.”. Science 266 (5186): 816–9. DOI:10.1126/science.7973638. PMID 7973638.
- Beckmann MP, Cerretti DP, Baum P, et al. (1994). „Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors.”. EMBO J. 13 (16): 3757–62. PMC 395287. PMID 8070404.
- Cerretti DP, Vanden Bos T, Nelson N, et al. (1996). „Isolation of LERK-5: a ligand of the eph-related receptor tyrosine kinases.”. Mol. Immunol. 32 (16): 1197–205. DOI:10.1016/0161-5890(95)00108-5. PMID 8559144.
- Gale NW, Holland SJ, Valenzuela DM, et al. (1996). „Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis.”. Neuron 17 (1): 9–19. DOI:10.1016/S0896-6273(00)80276-7. PMID 8755474.
- Stein E, Cerretti DP, Daniel TO (1996). „Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells.”. J. Biol. Chem. 271 (38): 23588–93. DOI:10.1074/jbc.271.38.23588. PMID 8798570.
- Bonaldo MF, Lennon G, Soares MB (1997). „Normalization and subtraction: two approaches to facilitate gene discovery.”. Genome Res. 6 (9): 791–806. DOI:10.1101/gr.6.9.791. PMID 8889548.
- Kozlosky CJ, VandenBos T, Park L, et al. (1997). „LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain.”. Cytokine 9 (8): 540–9. DOI:10.1006/cyto.1997.0199. PMID 9245480.
- Ephnomenclaturecommittee, (1997). „Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee.”. Cell 90 (3): 403–4. DOI:10.1016/S0092-8674(00)80500-0. PMID 9267020.
- Stein E, Huynh-Do U, Lane AA, et al. (1998). „Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase.”. J. Biol. Chem. 273 (3): 1303–8. DOI:10.1074/jbc.273.3.1303. PMID 9430661.
- Stein E, Lane AA, Cerretti DP, et al. (1998). „Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses.”. Genes Dev. 12 (5): 667–78. DOI:10.1101/gad.12.5.667. PMC 316584. PMID 9499402.