Malonatna dekarboksilaza zavisna od biotina
(Preusmjereno sa stranice EC 4.1.1.89)
Malonatna dekarboksilaza zavisna od biotina (EC 4.1.1.89, malonat dekarboksilaza (sa biotinom), malonat dekarboksilaza) je enzim sa sistematskim imenom malonat karboksilijaza (biotin-zavisna).[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju
Biotin-zavisna malonatna dekarboksilaza | |||||||||
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Identifikatori | |||||||||
EC broj | 4.1.1.89 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- malonat + H+ acetat + CO2
Pozanat su dva tipa malonatne dekarboksilaze. Oba su multienzimski kompleksi.
Reference uredi
- ↑ Hilbi, H., Dehning, I., Schink, B. and Dimroth, P. (1992). „Malonate decarboxylase of Malonomonas rubra, a novel type of biotin-containing acetyl enzyme”. Eur. J. Biochem. 207: 117-123. PMID 1628643.
- ↑ Hilbi, H. and Dimroth, P. (1994). „Purification and characterization of a cytoplasmic enzyme component of the Na+-activated malonate decarboxylase system of Malonomonas rubra: acetyl-S-acyl carrier protein: malonate acyl carrier protein-SH transferase”. Arch. Microbiol. 162: 48-56. PMID 18251085.
- ↑ Berg, M., Hilbi, H. and Dimroth, P. (1996). „The acyl carrier protein of malonate decarboxylase of Malonomonas rubra contains 2′-(5"-phosphoribosyl)-3′-dephosphocoenzyme A as a prosthetic group”. Biochemistry 35: 4689-4696. PMID 8664258.
- ↑ Berg, M., Hilbi, H. and Dimroth, P. (1997). „Sequence of a gene cluster from Malonomonas rubra encoding components of the malonate decarboxylase Na+ pump and evidence for their function”. Eur. J. Biochem. 245: 103-115. PMID 9128730.
- ↑ Micklefield, J., Harris, K.J., Gröger, S., Mocek, U., Hilbi, H., Dimroth, P. and Floss, H.G. (1995). „Stereochemical course of malonate decarboxylase in Malonomonas rubra has biotin decarboxylation with retention”. J. Am. Chem. Soc. 117: 1153-1154.
- ↑ Kim, Y.S. (2002). „Malonate metabolism: biochemistry, molecular biology, physiology, and industrial application”. J. Biochem. Mol. Biol. 35: 443-451. PMID 12359084.
- ↑ Dimroth, P. and Hilbi, H. (1997). „Enzymic and genetic basis for bacterial growth on malonate”. Mol. Microbiol. 25: 3-10. PMID 11902724.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.