Karbonil reduktaza (NADPH)
(Preusmjereno sa stranice EC 1.1.1.184)
Karbonil reduktaza (NADPH) (EC 1.1.1.184, aldehid reduktaza 1, prostaglandin 9-ketoreduktaza, ksenobiotik keton reduktaza, NADPH-zavisna karbonilna reduktaza, ALR3, karbonilna reduktaza, nespecifična NADPH-zavisna karbonilna reduktaza, karbonilna reduktaza (NADPH2)) je enzim sa sistematskim imenom sekundarni-alkohol:NADP+ oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Karbonil reduktaza (NADPH) | |||||||||
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| Tetramer karbonil reduktaze (miš) | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.1.1.184 | ||||||||
| CAS broj | 89700-36-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- R-CHOH-R' + NADP+ R-CO-R' + NADPH + H+
Ovaj enzim deluje na širok opseg karbonilnih jedinjenja, uključujući hinone, aromatične aldehide, ketoaldehide, daunorubicin i prostaglandine E and F, redukujući ih do korespondirajućih alkohola. On je B-specifičan u pogledu NADPH (cf. EC 1.1.1.2, alkohol dehidrogenaza (NADP+)).
Reference uredi
- ↑ Ahmed, N.K., Felsted, R.L. and Bachur, N.R. (1978). „Heterogeneity of anthracycline antibiotic carbonyl reductases in mammalian livers”. Biochem. Pharmacol. 27: 2713-2719. PMID 31888.
- ↑ Lin, Y.M. and Jarabak, J. (1978). „Isolation of two proteins with 9-ketoprostaglandin reductase and NADP-linked 15-hydroxyprostaglandin dehydrogenase activities and studies on their inhibition”. Biochem. Biophys. Res. Commun. 81: 1227-1234. PMID 666816.
- ↑ Wermuth, B. (1981). „Purification and properties of an NADPH-dependent carbonyl reductase from human brain. Relationship to prostaglandin 9-ketoreductase and xenobiotic ketone reductase”. J. Biol. Chem. 256: 1206-1213. PMID 7005231.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.