20a-hidroksisteroid dehidrogenaza
(Preusmjereno sa stranice EC 1.1.1.149)
20a-hidroksisteroid dehidrogenaza (EC 1.1.1.149, 20alfa-hidroksi steroidna dehidrogenaza, 20alfa-hidroksi steroid dehidrogenaza, 20alfa-HSD, 20alfa-HSDH) je enzim sa sistematskim imenom 20alfa-hidroksisteroid:NAD(P)+ 20-oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 20a-hidroksisteroid dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.149 | ||||||||
| CAS broj | 2608053 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 17alfa,20alfa-dihidroksipregn-4-en-3-on + NAD(P)+ 17alfa-hidroksiprogesteron + NAD(P)H + H+
20a-hidroksisteroid dehidrogenaza je specifična u pogledu NAD(P)+ (cf. EC 1.1.1.62 estradiol 17beta-dehidrogenaza).
Reference uredi
- ↑ Shikita, M., Inano, H. and Tamaoki, B. (1967). „Further studies on 20α-hydroxysteroid dehydrogenase of rat testes”. Biochemistry 6: 1760-1764. PMID 4382486.
- ↑ Strickler, R.C., Tobias, B. and Covey, D.F. (1981). „Human placental 17β-estradiol dehydrogenase and 20α-hydroxysteroid dehydrogenase. Two activities at a single enzyme active site”. J. Biol. Chem. 256: 316-321. PMID 6935192.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.