Dugolančana-masna-acil-KoA reduktaza
Dugolančana-masna-acil-KoA reduktaza (EC 1.2.1.50, acil-KoA reduktaza, acil koenzim A reduktaza) je enzim sa sistematskim imenom dugolančani aldehid:NADP+ oksidoreduktaza (formira acil-KoA).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Dugolančana-masna-acil-KoA reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.2.1.50 | ||||||||
| CAS broj | 50936-56-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- dugolančani aldehid + KoA + NADP+ dugolančani acil-KoA + NADPH + H+
Zajedno sa EC 6.2.1.19, ligazom dugolančane masne-kiseline---luciferin-komponente, formira reduktazni sistem masnih kiselina koji formura supstrat za EC 1.14.14.3, alkanalnu monooksigenazu (FMN-vezanu). Ona je deo bakterijskog luciferaznog sistema.
Reference
uredi- ↑ Riendeau, D., Rodrigues, A. and Meighen, E. (1982). „Resolution of the fatty acid reductase from Photobacterium phosphoreum into acyl protein synthetase and acyl-CoA reductase activities. Evidence for an enzyme complex”. J. Biol. Chem. 257: 6908-6915. PMID 7085612.
- ↑ Wall, L. and Meighen, E.A. (1986). „Subunit structure of the fatty-acid reductase complex from Photobacterium phosphoreum”. Biochemistry 25: 4315-4321.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.