Dipeptidilna peptidaza IV
Dipeptidilna peptidaza IV (EC 3.4.14.5, dipeptidilna aminopeptidaza IV, Xaa-Pro-dipeptidil-aminopeptidaza, Gly-Pro naftilamidaza, postprolin dipeptidil aminopeptidaza IV, limfocitni antigen CD26, glikoprotein GP110, glicilprolinska aminopeptidaza, X-prolil dipeptidil aminopeptidaza, pep X, leukocitni antigen CD26, glicilprolil dipeptidilaminopeptidaza, dipeptidil-peptidna hidrolaza, glicilprolilna aminopeptidaza, dipeptidil-aminopeptidaza IV, DPP IV/CD26, amino acil-prolil dipeptidil aminopeptidaza, T ćelijski inicirajući molekul Tp103, X-PDAP) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Dipeptidilna peptidaza IV | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 3.4.14.5 | ||||||||
| CAS broj | 54249-88-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- Odvajanje N-terminalnog dipeptida, Xaa-Yaa--Zaa-, sa polipeptida, preferentno kad je Yaa: Pro, i kad Zaa nije Pro niti hidroksiprolin
Ovaj enzim je homodimer. On je integralni protein ćelijske membrane limfocita i drugih sisarskih ćelija.
Reference
uredi- ↑ Misumi, Y., Hayashi, Y., Arakawa, F. and Ikehara, Y. (1992). „Molecular cloning and sequence analysis of human dipeptidyl peptidase IV, a serine proteinase on the cell surface”. Biochim. Biophys. Acta 1131: 333-336. PMID 1352704.
- ↑ David, F., Bernard, A.-M., Pierres, M. and Marguet, D. (1993). „Identification of serine 624, aspartic acid 702, and histidine 734 as the catalytic triad residues of mouse dipeptidyl-peptidase IV (CD26). A member of a novel family of nonclassical serine hydrolases”. J. Biol. Chem. 268: 17247-17252. PMID 8102366.
- ↑ Ikehara, Y., Ogata, S. and Misumi, Y. (1994). „Dipeptidyl-peptidase IV from rat liver”. Methods Enzymol. 244: 215-227. PMID 7845210.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.