Deuterolizin
Deuterolizin (EC 3.4.24.39, Penicillium roqueforti proteaza II, mikrobna neutralna proteinaza II, kiselinska metaloproteinaza, neutralna proteinaza II, Penicillium roqueforti metaloproteinaza) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Deuterolizin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.39 | ||||||||
| CAS broj | 247028-11-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Preferentno razlaanje veza sa hidrofobnim ostacima u P1'; takođe Asn3-Gln i Gly8-Ser veza u lancu insulina B
Ovaj enzim je prisutan u Penicillium roqueforti, P. caseicolum, Aspergillus sojae i A. Oryzae.
Reference uredi
- ↑ Nakadai, T., Nasuno, S. and Iguchi, N. (1973). „Purification and properties of neutral proteinase II from Aspergillus oryzae”. Agric. Biol. Chem. 37: 2703-2708.
- ↑ Gripon, J.-C. and Hermier, J. (1974). „Le système protéolytique de Penicillium roqueforti. III. Purification, propriétés et spécificité d’une protéase inhibée par l’E.D.T.A”. Biochimie 56: 1324-1332. PMID 4219726.
- ↑ Sekine, H. (1976). „, Neutral proteinases I and II of Aspergillus sojae action on various substrates”. Agric. Biol. Chem. 40: 703-709.
- ↑ Gripon, J.C., Auberger, B. and Lenoir, J. (1980). „Metalloproteases from Penicillium caseicolum and P. roqueforti: comparision of specificity and chemical characterization”. Int. J. Biochem. 12: 451-455. PMID 6998789.
- ↑ Vaganova, T.I., Ivanova, N.M. and Stepanov, V.M. (1988). „Isolation and properties of the "acid" metalloproteinase from Aspergillus oryzae”. Biochemistry (Mosc) 53: 1171-1178.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.