Desosaminil transferaza EryCIII
Desosaminil transferaza EryCIII (EC 2.4.1.278, EryCIII) je enzim sa sistematskim imenom dTDP-3-dimetilamino-4,6-didezoksi-alfa-D-glukopiranoza:3-alfa-mikarosileritronolid B 3-dimetilamino-4,6-didezoksi-alfa-D-glukoziltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Desosaminil transferaza EryCIII | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.278 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- dTDP-3-dimetilamino-4,6-didezoksi-alfa-D-glukopiranoza + 3-alfa-mikarosileritronolide B dTDP + eritromicin D
Ovaj enzim učestvuje u biosintezi eritromicina.
Reference uredi
- ↑ Yuan, Y., Chung, H.S., Leimkuhler, C., Walsh, C.T., Kahne, D. and Walker, S. (2005). „In vitro reconstitution of EryCIII activity for the preparation of unnatural macrolides”. J. Am. Chem. Soc. 127: 14128-14129. PMID 16218575.
- ↑ Lee, H.Y., Chung, H.S., Hang, C., Khosla, C., Walsh, C.T., Kahne, D. and Walker, S. (2004). „Reconstitution and characterization of a new desosaminyl transferase, EryCIII, from the erythromycin biosynthetic pathway”. J. Am. Chem. Soc. 126: 9924-9925. PMID 15303858.
- ↑ Moncrieffe, M.C., Fernandez, M.J., Spiteller, D., Matsumura, H., Gay, N.J., Luisi, B.F. and Leadlay, P.F. (2012). „Structure of the glycosyltransferase EryCIII in complex with its activating P450 homologue EryCII”. J. Mol. Biol. 415: 92-101. PMID 22056329.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.