Delta12-masna-kiselina desaturaza
Delta12-masna-kiselina desaturaza (EC 1.14.19.6, Delta12 masno kiselinska desaturaza, Delta12(omega6)-desaturaza, oleoil-KoA Delta12 desaturaza, Delta12 desaturaza, Delta12-desaturaza) je enzim sa sistematskim imenom acil-KoA,vodonik donor:kiseonik Delta12-oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju:
| Delta12-masna-kiselina desaturaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.19.6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- acil-KoA + redukovani akceptor + O2 Delta12-acil-KoA + akceptor + 2H2O
U kvascu Lipomyces starkeyi i američkoj bubašvabi, ovaj mikrozomalni enzim konvertuje oleoil-KoA u linoleoil-KoA. Kod moljaca Cadra cautella i Spodoptera, on konvertuje (Z)-tetradek-9-enoinsku kiselinu (9Z,12E)-tetradeka-9,12-dienoinsku kiselinu, koja se redukuje i acetiluje čime se formira acetatni estar feromona.
Reference
uredi- ↑ Borgeson, C.E., de Renobales, M. and Blomquist, G.J. (1990). „Characterization of the Δ12 desaturase in the American cockroach, Periplaneta americana: the nature of the substrate”. Biochim. Biophys. Acta 1047: 135-140. PMID 2248971.
- ↑ Jurenka, R.A. (1997). „Biosynthetic pathway for producing the sex pheromone component (Z,E)-9,12-tetradecadienyl acetate in moths involves a Δ12 desaturase”. Cell. Mol. Life Sci. 53: 501-505. PMID 9230926.
- ↑ Lomascolo, A., Dubreucq, E. and Galzy, P. (1996). „Study of the Δ12-desaturase system of Lipomyces starkeyi”. Lipids 31: 253-259. PMID 8900454.
- ↑ Tocher, D.R., Leaver, M.J. and Hodgson, P.A. (1998). „Recent advances in the biochemistry and molecular biology of fatty acyl desaturases”. Prog. Lipid Res. 37: 73-117. PMID 9829122.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.