Dekaprenilfosfo-beta-D-ribofuranoza 2-oksidaza
Dekaprenilfosfo-beta-D-ribofuranoza 2-oksidaza (EC 1.1.98.3, dekaprenilfosforil-beta-D-ribofuranozna 2'-epimeraza, Rv3790, DprE1) je enzim sa sistematskim imenom trans,oktacis-dekaprenilfosfo-beta-D-ribofuranoza:FAD 2-oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Dekaprenilfosfo-beta-D-ribofuranoza 2-oksidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.98.3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- trans,octacis-dekaprenilfosfo-beta-D-ribofuranoza + FAD trans,octacis-dekaprenilfosfo-beta-D-eritro-pentofuranozid-2-uloza + FADH2
Ovaj enzim, izolovan iz bakterije Mycobakterija smegmatis, učestvuje zajedno sa EC 1.1.1.333, dekaprenilfosfo-D-eritro-pentofuranozid-2-uloza 2-reduktazom, u epimerizaciji trans,oktacis-dekaprenilfosfo-beta-D-ribofuranoz do trans,octacis-dekaprenilfosfo-beta-D-arabinofuranoze, arabinozilnog donora za biosintezu arabinanskih polimera mikobakterijskog ćelijskog zida.
Reference uredi
- ↑ Ribeiro, A.L., Degiacomi, G., Ewann, F., Buroni, S., Incandela, M.L., Chiarelli, L.R., Mori, G., Kim, J., Contreras-Dominguez, M., Park, Y.S., Han, S.J., Brodin, P., Valentini, G., Rizzi, M., Riccardi, G. and Pasca, M.R. (2011). „Analogous mechanisms of resistance to benzothiazinones and dinitrobenzamides in Mycobacterium smegmatis”. PLoS One 6: #e26675-e26675. PMID 22069462.
- ↑ Trefzer, C., Škovierová, H., Buroni, S., Bobovská, A., Nenci, S., Molteni, E., Pojer, F., Pasca, M.R., Makarov, V., Cole, S.T., Riccardi, G., Mikušová, K. and Johnsson, K. (2012). „Benzothiazinones are suicide inhibitors of mycobacterial decaprenylphosphoryl-β-D-ribofuranose 2′-oxidase DprE1”. J. Am. Chem. Soc. 134: 912-915. PMID 22188377.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.