Deacetilcefalosporin-C acetiltransferaza
Deacetilcefalosporin-C acetiltransferaza (EC 2.3.1.175, acetil-KoA:deacetilcefalosporin-C acetiltransferaza, DAC acetiltransferaza, cefG, deacetilcefalosporin C acetiltransferaza, acetil koenzim A:DAC acetiltransferaza, acetil-KoA:DAC acetiltransferaza, CPC acetilhidrolaza, acetil-KoA:DAC O-acetiltransferaza, DAC-AT) je enzim sa sistematskim imenom acetil-KoA:deacetilcefalosporin-C O-acetiltransferaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Deacetilcefalosporin-C acetiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.175 | ||||||||
| CAS broj | 57827-76-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- acetil-KoA + deacetilcefalosporin C KoA + cefalosporin C
Ovaj enzim katalizuje finalni korak u biosintezi cefalosporina C.
Reference
uredi- ↑ Matsuyama, K., Matsumoto, H., Matsuda, A., Sugiura, H., Komatsu, K. and Ichikawa, S. (1992). „Purification of acetyl coenzyme A: deacetylacephalosporin C O-acetyltransferase from Acremonium chrysogenum”. Biosci. Biotechnol. Biochem. 56: 1410-1412. PMID 1368946.
- ↑ Gutiérrez, S., Velasco, J., Fernandez, F.J. and Martín, J.F. (1992). „The cefG gene of Cephalosporium acremonium is linked to the cefEF gene and encodes a deacetylcephalosporin C acetyltransferase closely related to homoserine O-acetyltransferase”. J. Bacteriol. 174: 3056-3064. PMID 1569032.
- ↑ Matsuda, A., Sugiura, H., Matsuyama, K., Matsumoto, H., Ichikawa, S. and Komatsu, K. (1992). „Cloning and disruption of the cefG gene encoding acetyl coenzyme A: deacetylcephalosporin C O-acetyltransferase from Acremonium chrysogenum”. Biochem. Biophys. Res. Commun. 186: 40-46. PMID 1632779.
- ↑ Gutiérrez, S., Velasco, J., Marcos, A.T., Fernández, F.J., Fierro, F., Barredo, J.L., Díez, B. and Martín, J.F. (1997). „Expression of the cefG gene is limiting for cephalosporin biosynthesis in Acremonium chrysogenum”. Appl. Microbiol. Biotechnol. 48: 606-614. PMID 9421924.
- ↑ Velasco, J., Gutierrez, S., Campoy, S. and Martin, J.F. (1999). „Molecular characterization of the Acremonium chrysogenum cefG gene product: the native deacetylcephalosporin C acetyltransferase is not processed into subunits”. Biochem. J. 337: 379-385. PMID 9895280.
- ↑ Martín, J.F., Gutiérrez, S., Fernández, F.J., Velasco, J., Fierro, F., Marcos, A.T. and Kosalkova, K. (1994). „Expression of genes and processing of enzymes for the biosynthesis of penicillins and cephalosporins”. Antonie Van Leeuwenhoek 65: 227-243. PMID 7847890.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.