Damarenediolna II sintaza
Damarenediolna II sintaza (EC 4.2.1.125, damarenediolna sintaza, 2,3-oksidoskvalen (20S)-dammarenediol ciklaza, DDS, (S)-skvalen-2,3-epoksid hidrolijaza (formira damarenediol-II)) je enzim sa sistematskim imenom (3S)-2,3-epoksi-2,3-dihidroskvalen hidrolijaza (formira dammarenediol-II).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Damarenediolna II sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.1.125 | ||||||||
| CAS broj | 189354-84-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- damarenediol II (3S)-2,3-epoksi-2,3-dihidroskvalen + H2O
Ova reakcija se odvija u reverznom smeru.
Reference uredi
- ↑ Tansakul, P., Shibuya, M., Kushiro, T. and Ebizuka, Y. (2006). „Dammarenediol-II synthase, the first dedicated enzyme for ginsenoside biosynthesis, in Panax ginseng”. FEBS Lett. 580: 5143-5149. PMID 16962103.
- ↑ Han, J.Y., Kwon, Y.S., Yang, D.C., Jung, Y.R. and Choi, Y.E. (2006). „Expression and RNA interference-induced silencing of the dammarenediol synthase gene in Panax ginseng”. Plant Cell Physiol. 47: 1653-1662. PMID 17088293.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.