DUTP difosfataza
(Preusmjereno sa stranice DUTP nucleotidohydrolase)
DUTP difosfataza (EC 3.6.1.23, dezoksiuridin-trifosfataza, dUTPaza, dUTP pirofosfataza, dezoksiuridin 5'-trifosfatna nukleotidohidrolaza, desoksiuridinska 5'-trifosfataza) je enzim sa sistematskim imenom dUTP nukleotidohidrolaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| DUTP difosfataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Trimer DUTP difosfataze (čovjek) | |||||||||
| Identifikatori | |||||||||
| EC broj | 3.6.1.23 | ||||||||
| CAS broj | 37289-34-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- dUTP + H2O dUMP + difosfat
Reference
uredi- ↑ Bertani, L.E., Häggmark, A. and Reichard, P. (1963). „Enzymatic synthesis of deoxyribonucleotides. II. Formation and interconversion of deoxyuridine phosphates”. J. Biol. Chem. 238: 3407-3413. PMID 14085395.
- ↑ Giroir, L.E. and Deutsch, W.A. (1987). „Drosophila deoxyuridine triphosphatase. Purification and characterization”. J. Biol. Chem. 262: 130-134. PMID 3025197.
- ↑ Greenberg, G.R. and Somerville, R.L. (1962). „Deoxyuridylate kinase activity and deoxyuridinetriphosphatase in Escherichia coli”. Proc. Natl. Acad. Sci. USA 48: 247-257. PMID 13901467.
- ↑ Grindey, G.B. and Nichol, C.A. (1971). „Mammalian deoxyuridine 5′-triphosphate pyrophosphatase”. Biochim. Biophys. Acta 240: 180-183. PMID 5105331.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.