DNK nukleotidileksotransferaza
DNK nukleotidileksotransferaza (EC 2.7.7.31, terminal dezoksiribonukleotidiltransferaza, terminal addition enzim, addase, dezoksinukleotidil terminal transferaza, dezoksiribonukleinska kiselina nukleotidiltransferaza, dezoksiribonukleinska nukleotidiltransferaza, terminal dezoksinukleotid transferaza, TdT) je enzim sa sistematskim imenom nukleozid-trifosfat:DNK dezoksinukleotidileksotransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| DNK nukleotidileksotransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Identifikatori | |||||||||
| EC broj | 2.7.7.31 | ||||||||
| CAS broj | 9027-67-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- dezoksinukleozid trifosfat + DNKn difosfat + DNKn+1
Ovaj enzim katalizuje od okvira nezavisno produžavanje 3'-kraja DNK lanca.
Reference uredi
- ↑ Bollum, F.J. (1971). „Deoxynucleotide-polymerizing enzymes of calf thymus gland. V. Homogeneous terminal deoxynucleotidyl transferase”. J. Biol. Chem. 246: 909-916. PMID 5543689.
- ↑ Gottesman, M.E. and Canellakis, E.S. (1966). „The terminal nucleotidyltransferases of calf thymus nuclei”. J. Biol. Chem. 241: 4339-4352. PMID 4288534.
- ↑ Krakow, J.S., Coutsogeorgopoulos, C. and Canellakis, E.S. (1962). „Studies on the incorporation of deoxyribonucleic acid”. Biochim. Biophys. Acta 55: 639-650. PMID 14459258.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.