DNK (citozin-5-)-metiltransferaza
DNK (citozin-5-)-metiltransferaza (EC 2.1.1.37, EcoRI metilaza, DNK 5-citozinska metilaza, DNK citozinska C5 metilaza, DNK citozinska metilaza, DNK metilaza, DNK metiltransferaza, DNK transmetilaza, DNK-citozinska 5-metilaza, DNK-citozinska metiltransferaza, HpaII metilaza, HpaII' metilaza, M.BsuRIa, M.BsuRIb, Tip II DNK metilaza, citozinska 5-metiltransferaza, citozinska DNK metilaza, citozinska DNK metiltransferaza, citozin-specifična DNK metiltransferaza, dezoksiribonukleinska metilaza, dezoksiribonukleinska metiltransferaza, dezoksiribonukleinska (citozin-5-)-metiltransferaza, dezoksiribonukleinska kiselina (citozin-5-)-metiltransferaza, dezoksiribonukleinska kiselina metilaza, dezoksiribonukleinska kiselina metiltransferaza, metilaza modifikacije dezoksiribonukleinske kiseline, dezoksiribonukleinska metilaza, metilfosfotriester-DNK metiltransferaza, modifikaciona metilaza, restrikciono-modifikacioni sistem, site-specifična DNK-metiltransferaza (citozin-specifična), DNK-(citozin C5)-metilaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:DNK (citozin-5-)-metiltransferaza.[1][2][3][4][5][6][7][8][9] Ovaj enzim katalizuje sledeću hemijsku reakciju
| DNK (citozin-5-)-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Identifikatori | |||||||||
| EC broj | 2.1.1.37 | ||||||||
| CAS broj | 9037-42-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | structures | ||||||||
| |||||||||
- S-adenozil-L-metionin + DNK citozin S-adenozil-L-homocistein + DNK 5-metilcitozin
ReferenceUredi
- ↑ Gold, M. and Hurwitz, J. (1964). "The enzymatic methylation of ribonucleic acid and deoxyribonucleic acid. V. Purification and properties of the deoxyribonucleic acid-methylating activity of Escherichia coli". J. Biol. Chem. 239: 3858-2865. PMID 14257620.
- ↑ Kalousek, F. and Morris, N.R. (1969). "The purification and properties of deoxyribonucleic acid methylase from rat spleen". J. Biol. Chem. 244: 1157-1163. PMID 4975067.
- ↑ Roy, P.H. and Weissbach, A. (1975). "DNA methylase from HeLa cell nuclei". Nucleic Acids Res. 2: 1669-1684. PMID 1187340.
- ↑ Simon, D., Grunert, F., Acken, U.Y., Döring, H.P. and Kröger, H. (1978). "DNA-methylase from regenerating rat liver: purification and characterisation". Nucleic Acids Res. 5: 2153-2167. PMID 673848.
- ↑ Sneider, T.W., Teague, W.M. and Rogachewsky, L.M. (1975). "S-Adenosylmethionine: DNA-cytosine 5-methyltransferase from a Novikoff rat hepatoma cell line". Nucleic Acids Res. 2: 1685-1700. PMID 171625.
- ↑ Turnbull, J.F. and Adams, R.L.P. (1976). "DNA methylase: purification from ascites cells and the effect of various DNA substrates on its activity". Nucleic Acids Res. 3: 677-695. PMID 131936.
- ↑ Kessler, C. and Manta, V. (1990). "Specificity of restriction endonucleases and DNA modification methyltransferases: a review". Gene 92: 1-248. PMID 2172084.
- ↑ Roberts, R.J. (1990). "Restriction enzymes and their isoschizomers". Nucleic Acids Res. 18: 2331-2365. PMID 2159140.
- ↑ Yuan, R. (1981). "Structure and mechanism of multifunctional restriction endonucleases". Annu. Rev. Biochem. 50: 285-319. PMID 6267988.
LiteraturaUredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. http://books.google.com/books/about/Fundamentals_of_enzymology.html?id=8uvwAAAAMAAJ.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. http://books.google.com/books/about/Advances_in_Enzymology_and_Related_Areas.html?id=Pmh8yToeuloC.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. http://www.garlandscience.com/textbooks/0815323042.asp?type=reviews.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. http://books.google.com/books/about/Enzyme_Kinetics.html?id=T60oAAAAYAAJ.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. http://books.google.com/books/about/Evaluation_of_Enzyme_Inhibitors_in_Drug.html?id=l2rMy8QNUk0C.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. http://books.google.com/books/about/Biochemical_pathways.html?id=081qAAAAMAAJ.