DNK nukleotidileksotransferaza
(Preusmjereno sa stranice DNA nucleotidylexotransferase)
DNK nukleotidileksotransferaza (EC 2.7.7.31, terminal dezoksiribonukleotidiltransferaza, terminal addition enzim, addase, dezoksinukleotidil terminal transferaza, dezoksiribonukleinska kiselina nukleotidiltransferaza, dezoksiribonukleinska nukleotidiltransferaza, terminal dezoksinukleotid transferaza, TdT) je enzim sa sistematskim imenom nukleozid-trifosfat:DNK dezoksinukleotidileksotransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
DNK nukleotidileksotransferaza | |||||||||
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Identifikatori | |||||||||
EC broj | 2.7.7.31 | ||||||||
CAS broj | 9027-67-2 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- dezoksinukleozid trifosfat + DNKn difosfat + DNKn+1
Ovaj enzim katalizuje od okvira nezavisno produžavanje 3'-kraja DNK lanca.
Reference uredi
- ↑ Bollum, F.J. (1971). „Deoxynucleotide-polymerizing enzymes of calf thymus gland. V. Homogeneous terminal deoxynucleotidyl transferase”. J. Biol. Chem. 246: 909-916. PMID 5543689.
- ↑ Gottesman, M.E. and Canellakis, E.S. (1966). „The terminal nucleotidyltransferases of calf thymus nuclei”. J. Biol. Chem. 241: 4339-4352. PMID 4288534.
- ↑ Krakow, J.S., Coutsogeorgopoulos, C. and Canellakis, E.S. (1962). „Studies on the incorporation of deoxyribonucleic acid”. Biochim. Biophys. Acta 55: 639-650. PMID 14459258.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.